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LRP1B
Description
LDL receptor related protein 1B
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Receptor Complex
Molecular Function
Low-density Lipoprotein Particle Receptor Activity
Calcium Ion Binding
Protein Binding
Biological Process
Endocytosis
Receptor-mediated Endocytosis
Protein Transport
Pathways
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Adventurousness (
30643258
)
Adverse response to drug (
30420678
)
Aging (
19367585
)
Asthma (childhood onset) (
27611488
)
Asthma and eczema (
34155719
)
Blood pressure (smoking interaction) (
25189868
)
Body mass index (
25673413
20935630
28892062
)
Body size at age 10 (
32376654
)
Cataracts (
34127677
)
Cerebellum white matter volume (
31530798
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Cognitive performance (processing speed) (
31598132
)
Congenital heart disease (inherited effect) (
28468790
)
Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes (
29221444
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Dietary fat liking (
32516399
)
Diffusing capacity of carbon monoxide (
30694715
)
Diisocyanate-induced asthma (
25918132
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Estimated glomerular filtration rate (
31217584
)
Facial attractiveness (male raters) (
30946739
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Hepcidin/ferritin ratio (
27846281
)
Household income (MTAG) (
31844048
)
Influenza A (H1N1) infection (
26379185
)
Keratoconus (
33649486
)
Lung adenocarcinoma (
28604730
)
Menarche (age at onset) (
21102462
25231870
)
Mood instability (
31168069
)
Motion sickness (
25628336
)
Night sleep phenotypes (
27126917
)
Number of sexual partners (
30643258
)
Optic nerve measurement (disc area) (
20395239
)
Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma (
29551627
)
Periodontitis (CDC/AAP) (
24024966
)
Post bronchodilator FEV1 (
26634245
)
Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (
34099189
)
Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction (
34099189
)
Severe influenza A (H1N1) infection (
26379185
)
Type 1 diabetes (
32005708
)
Type 2 diabetes (
30130595
)
Novel Interacting Genes
2 novel interacting genes:
EVL
PABPC1
Interacting Genes
8 interacting genes:
APP
DYRK1A
FGA
LCOR
LRPAP1
PLAT
PLAUR
SERPINE1
Entrez ID
53353
HPRD ID
16383
Ensembl ID
ENSG00000168702
Uniprot IDs
Q9NZR2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Signaling Receptor Binding
Regulation Of Hemostasis
Regulation Of Protein Maturation
Regulation Of Blood Coagulation
Regulation Of Fibrinolysis
Regulation Of Plasminogen Activation
Fibrinolysis
Negative Regulation Of Protein Maturation
Regulation Of Wound Healing
Regulation Of Response To Wounding
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Serine Protease Inhibitor Complex
Regulation Of Protein Metabolic Process
Regulation Of Protein Processing
Platelet Alpha Granule Lumen
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Wound Healing
Negative Regulation Of Gene Expression
Regulation Of Body Fluid Levels
Cell Surface
Negative Regulation Of Multicellular Organismal Process
Plasminogen Activation
Negative Regulation Of Fibrinolysis
Blood Coagulation
Coagulation
Hemostasis
Regulation Of Receptor-mediated Endocytosis
Regulation Of Proteolysis
Negative Regulation Of Signal Transduction
Negative Regulation Of Macromolecule Biosynthetic Process
Platelet Alpha Granule
Regulation Of Apoptotic Signaling Pathway
Regulation Of Amyloid-beta Clearance
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Signaling
Endosome Lumen
Negative Regulation Of Cell Communication
Negative Regulation Of Protein Processing
Positive Regulation Of Monocyte Chemotaxis
Regulation Of Extrinsic Apoptotic Signaling Pathway
Low-density Lipoprotein Particle Receptor Binding
Positive Regulation Of Blood Coagulation
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Coagulation
Regulation Of Biological Quality
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Monocyte Chemotaxis
Negative Regulation Of Endothelial Cell Apoptotic Process
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