LRP1B and PLAUR

Number of citations of the paper that reports this interaction (PubMedID 12194987)
0

Data Source:
HPRD (in vivo)

		LRP1B	PLAUR
Description		LDL receptor related protein 1B	plasminogen activator, urokinase receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extrinsic Component Of Membrane Specific Granule Membrane Cell Projection Anchoring Junction Side Of Membrane Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Protein Transport	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Plasminogen Activation Regulation Of Cell Adhesion Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs			Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Aging ( 19367585) Asthma (childhood onset) ( 27611488) Asthma and eczema ( 34155719) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 25673413 20935630 28892062) Body size at age 10 ( 32376654) Cataracts ( 34127677) Cerebellum white matter volume ( 31530798) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive performance (processing speed) ( 31598132) Congenital heart disease (inherited effect) ( 28468790) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dietary fat liking ( 32516399) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31217584) Facial attractiveness (male raters) ( 30946739) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Hepcidin/ferritin ratio ( 27846281) Household income (MTAG) ( 31844048) Influenza A (H1N1) infection ( 26379185) Keratoconus ( 33649486) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 21102462 25231870) Mood instability ( 31168069) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Optic nerve measurement (disc area) ( 20395239) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Periodontitis (CDC/AAP) ( 24024966) Post bronchodilator FEV1 ( 26634245) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Severe influenza A (H1N1) infection ( 26379185) Type 1 diabetes ( 32005708) Type 2 diabetes ( 30130595)	Basophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		8 interacting genes: APP DYRK1A FGA LCOR LRPAP1 PLAT PLAUR SERPINE1	22 interacting genes: CRYAA DYRK1A EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		53353	5329
HPRD ID		16383	01421
Ensembl ID		ENSG00000168702	ENSG00000011422
Uniprot IDs		Q9NZR2	M0R1I2 Q03405
PDB IDs			1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI 7E17 7V63
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Regulation Of Hemostasis Regulation Of Protein Maturation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Fibrinolysis Negative Regulation Of Protein Maturation Regulation Of Wound Healing Regulation Of Response To Wounding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Serine Protease Inhibitor Complex Regulation Of Protein Metabolic Process Regulation Of Protein Processing Platelet Alpha Granule Lumen Negative Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Negative Regulation Of Gene Expression Regulation Of Body Fluid Levels Cell Surface Negative Regulation Of Multicellular Organismal Process Plasminogen Activation Negative Regulation Of Fibrinolysis Blood Coagulation Coagulation Hemostasis Regulation Of Receptor-mediated Endocytosis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Platelet Alpha Granule Regulation Of Apoptotic Signaling Pathway Regulation Of Amyloid-beta Clearance Negative Regulation Of Biosynthetic Process Negative Regulation Of Signaling Endosome Lumen Negative Regulation Of Cell Communication Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Blood Coagulation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Coagulation Regulation Of Biological Quality Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Monocyte Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process	Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Tyrosine Kinase Activity Focal Adhesion Regulation Of Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wound Healing Type II Interferon-mediated Signaling Pathway Regulation Of Fibrinolysis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Blood Coagulation Cell Surface Receptor Signaling Pathway Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Receptor-mediated Endocytosis Regulation Of Multicellular Organismal Process Cell Motility Protein Phosphorylation Regulation Of Cell Adhesion Membrane Raft Phosphorylation Extracellular Space Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Regulation Of Protein Metabolic Process Cell Migration Plasma Membrane Endocytosis Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Motility Interleukin-11-mediated Signaling Pathway Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Protein Kinase Activity Integrin Binding Negative Regulation Of Coagulation Regulation Of Locomotion Protein Complex Involved In Cell-matrix Adhesion Response To Amyloid-beta Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Developmental Process Positive Regulation Of Wound Healing Positive Regulation Of Reactive Oxygen Species Metabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT
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