LRP1B and PLAUR

Number of citations of the paper that reports this interaction (PMID 11384978)
14

Data Source:
HPRD (in vivo)

		LRP1B	PLAUR
Gene Name		low density lipoprotein receptor-related protein 1B	plasminogen activator, urokinase receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Receptor Complex	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome Invadopodium Membrane
	Molecular Function	Low-density Lipoprotein Receptor Activity Calcium Ion Binding	Receptor Activity Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity
	Biological Process	Receptor-mediated Endocytosis Protein Transport	C-terminal Protein Lipidation Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction Blood Coagulation Attachment Of GPI Anchor To Protein Regulation Of Proteolysis Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Attachment of GPI anchor to uPAR Dissolution of Fibrin Clot Post-translational modification: synthesis of GPI-anchored proteins
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase
Diseases
GWAS		Aging ( 19367585) Body mass index ( 20935630) Erectile dysfunction and prostate cancer treatment ( 20932654) Menarche (age at onset) ( 21102462) Optic disc size (disc) ( 20395239)
Protein-Protein Interactions		5 interactors: APP LRPAP1 PLAT PLAUR SERPINE1	20 interactors: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		53353	5329
HPRD ID		16383	01421
Ensembl ID		ENSG00000168702	ENSG00000011422
Uniprot IDs		Q9NZR2	M0R1I2 Q03405
PDB IDs			1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74
Enriched GO Terms of Interacting Partners?		Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Receptor Activity Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Degranulation Negative Regulation Of Vascular Wound Healing Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Protein Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ovulation Regulation Of Smooth Muscle Cell-matrix Adhesion Collateral Sprouting In Absence Of Injury Chronological Cell Aging Negative Regulation Of Beta-amyloid Clearance Platelet Activation Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Vascular Wound Healing Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Signaling Axon Choice Point Recognition Regulation Of Beta-amyloid Clearance Negative Regulation Of Cell Adhesion Mediated By Integrin Locomotion Cell Surface Receptor Signaling Pathway Plasminogen Activation Negative Regulation Of Plasminogen Activation Neuron Remodeling Exocytosis	Cell Motility Cell Migration Locomotion Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune Response Regulation Of Cell Proliferation Regulation Of Collagen Catabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Immune System Process Regulation Of Cell Migration Regulation Of Smooth Muscle Cell Migration Defense Response Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Motility Developmental Process Endocytosis Regulation Of Apoptotic Process Negative Regulation Of Blood Coagulation Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Negative Regulation Of Coagulation Regulation Of Cell Death Blood Coagulation Hemostasis Protein Autophosphorylation Negative Regulation Of Wound Healing Cell Adhesion Leukocyte Migration Innate Immune Response Regulation Of Innate Immune Response Cell Adhesion Mediated By Integrin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Blood Coagulation Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Vesicle-mediated Transport Activated T Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cellular Process Regulation Of Defense Response To Virus By Virus Positive Regulation Of Cell Adhesion Extracellular Matrix Organization
Tagcloud ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Difference) ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	alters ap attributed cascade chemo chief designating erk1 fos fra govern isoform mapk microrna mir mirna multifaceted next oncogenic serpine1 shortening singular snail thousands transcriptome transcriptomes tumorigenesis utrs zeb1
Tagcloud (Intersection) ?