LRP1B and SERPINE1

Number of citations of the paper that reports this interaction (PMID 11384978)
14

Data Source:
HPRD (in vivo)

		LRP1B	SERPINE1
Gene Name		low density lipoprotein receptor-related protein 1B	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Low-density Lipoprotein Receptor Activity Calcium Ion Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding
	Biological Process	Receptor-mediated Endocytosis Protein Transport	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone
Diseases
GWAS		Aging ( 19367585) Body mass index ( 20935630) Erectile dysfunction and prostate cancer treatment ( 20932654) Menarche (age at onset) ( 21102462) Optic disc size (disc) ( 20395239)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		5 interactors: APP LRPAP1 PLAT PLAUR SERPINE1	19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN
Entrez ID		53353	5054
HPRD ID		16383	01418
Ensembl ID		ENSG00000168702	ENSG00000106366
Uniprot IDs		Q9NZR2	P05121
PDB IDs			1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI
Enriched GO Terms of Interacting Partners?		Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Receptor Activity Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Degranulation Negative Regulation Of Vascular Wound Healing Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Protein Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ovulation Regulation Of Smooth Muscle Cell-matrix Adhesion Collateral Sprouting In Absence Of Injury Chronological Cell Aging Negative Regulation Of Beta-amyloid Clearance Platelet Activation Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Vascular Wound Healing Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Signaling Axon Choice Point Recognition Regulation Of Beta-amyloid Clearance Negative Regulation Of Cell Adhesion Mediated By Integrin Locomotion Cell Surface Receptor Signaling Pathway Plasminogen Activation Negative Regulation Of Plasminogen Activation Neuron Remodeling Exocytosis	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion
Tagcloud ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2
Tagcloud (Difference) ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2
Tagcloud (Intersection) ?