LRP1B and PLAT

Number of citations of the paper that reports this interaction (PMID 11384978)
14

Data Source:
HPRD (in vivo)

		LRP1B	PLAT
Gene Name		low density lipoprotein receptor-related protein 1B	plasminogen activator, tissue
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Extracellular Matrix Apical Part Of Cell Synapse Extracellular Vesicular Exosome
	Molecular Function	Low-density Lipoprotein Receptor Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Protein Binding
	Biological Process	Receptor-mediated Endocytosis Protein Transport	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Synaptic Transmission, Glutamatergic Fibrinolysis Response To Peptide Hormone Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To CAMP Transmembrane Transport Positive Regulation Of Ovulation Cellular Response To Dexamethasone Stimulus
Pathways			Signaling by PDGF Dissolution of Fibrin Clot Orphan transporters
Drugs			Urokinase Aminocaproic Acid Ibuprofen Iloprost 6-Amino Hexanoic Acid 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Diseases
GWAS		Aging ( 19367585) Body mass index ( 20935630) Erectile dysfunction and prostate cancer treatment ( 20932654) Menarche (age at onset) ( 21102462) Optic disc size (disc) ( 20395239)
Protein-Protein Interactions		5 interactors: APP LRPAP1 PLAT PLAUR SERPINE1	25 interactors: ANXA2 CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LAMA5 LRP1 LRP1B MAPK1 MAPK3 PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC
Entrez ID		53353	5327
HPRD ID		16383	01419
Ensembl ID		ENSG00000168702	ENSG00000104368
Uniprot IDs		Q9NZR2	B4DN26 B4DNJ1 P00750
PDB IDs			1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
Enriched GO Terms of Interacting Partners?		Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Blood Coagulation Regulation Of Receptor Activity Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Degranulation Negative Regulation Of Vascular Wound Healing Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Protein Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ovulation Regulation Of Smooth Muscle Cell-matrix Adhesion Collateral Sprouting In Absence Of Injury Chronological Cell Aging Negative Regulation Of Beta-amyloid Clearance Platelet Activation Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Vascular Wound Healing Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Signaling Axon Choice Point Recognition Regulation Of Beta-amyloid Clearance Negative Regulation Of Cell Adhesion Mediated By Integrin Locomotion Cell Surface Receptor Signaling Pathway Plasminogen Activation Negative Regulation Of Plasminogen Activation Neuron Remodeling Exocytosis	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Fibrinolysis Wound Healing Negative Regulation Of Coagulation Platelet Activation Negative Regulation Of Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Cell Migration Regulation Of Blood Coagulation Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Wound Healing Vesicle-mediated Transport Cardiovascular System Development Regulation Of Cell Adhesion Multicellular Organismal Development Developmental Process Cell Activation System Development Anatomical Structure Development Blood Vessel Development Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Vesicle-mediated Transport Regulation Of Catalytic Activity Response To Stress Exocytosis Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cellular Protein Metabolic Process Receptor-mediated Endocytosis Response To Stimulus Regulation Of Cell-substrate Adhesion Locomotion Secretion Regulation Of Peptidase Activity Extracellular Matrix Disassembly Blood Vessel Morphogenesis Regulation Of Smooth Muscle Cell-matrix Adhesion Response To External Stimulus Regulation Of Golgi Inheritance Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component
Tagcloud ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Difference) ?		adiposity brown bxh2 classes cub determinants encompassing fractions haplotype inbred lipoprotein lx microsatellite norway permutations polymorphic pxo segregate shr silico spanning subdivision sucrose suggestive tg trait traits triglyceride vldl	10th 9th abundantly african crab cterminus eating evolutionary exonization exons harbor hominoids intriguingly intron l3 l3b marmoset monkey monkeys primate prosimian ran rhesus te tes transposable varies world zranb2
Tagcloud (Intersection) ?