CASP8 and APAF1

Number of citations of the paper that reports this interaction (PMID 9539746)
61

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CASP8	APAF1
Gene Name		caspase 8, apoptosis-related cysteine peptidase	apoptotic peptidase activating factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Noc1p-Noc2p Complex Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Death Effector Domain Binding Protein Heterodimerization Activity Scaffold Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding
	Biological Process	Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Cold Viral Process Natural Killer Cell Activation Macrophage Differentiation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Response To Antibiotic Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Thymocyte Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Hepatocyte Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		TRAIL signaling Death Receptor Signalling Caspase-8 activation by cleavage FasL/ CD95L signaling Activation, myristolyation of BID and translocation to mitochondria Caspase-mediated cleavage of cytoskeletal proteins Activated TLR4 signalling NOD1/2 Signaling Pathway Programmed Cell Death TRIF-mediated programmed cell death Innate Immune System Intrinsic Pathway for Apoptosis Regulation by c-FLIP Apoptotic cleavage of cellular proteins Dimerization of procaspase-8 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway	Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs			Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS		Melanoma ( 21983787)
Protein-Protein Interactions		91 interactors: APAF1 APP AR ATG4D BCAP31 BCL2 BCL2L1 BFAR BID BIRC6 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CDH1 CDK11B CDKN1B CFLAR CHD3 CHUK COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 FADD FAF1 FAS FYN GMEB1 GRIA1 GZMB HDAC7 HECTD3 HIP1 IKBKB IKBKG ILK KRT18 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 PARK2 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PLA2G4B PLEC PLIN4 PRDX6 PRKCI PRKCZ PSEN1 PSEN2 RALBP1 RB1 RIPK1 RIPK2 RYBP SNRPD3 SRF STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 USO1 VIM	18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1
Entrez ID		841	317
HPRD ID		03459	03755
Ensembl ID		ENSG00000064012	ENSG00000120868
Uniprot IDs		Q14790	O14727
PDB IDs		1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Signal Transduction Regulation Of Peptidase Activity Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signaling Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Execution Phase Of Apoptosis Negative Regulation Of Cell Death Regulation Of Metabolic Process	Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially
Tagcloud (Intersection) ?