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CASP8 and BRD1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
CASP8
BRD1
Description
caspase 8
bromodomain containing 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Cell Projection
Cell Body
Ripoptosome
Nucleus
Chromosome
Nuclear Speck
Dendrite
Histone H3-K14 Acetyltransferase Complex
Perikaryon
MOZ/MORF Histone Acetyltransferase Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Protein Binding
Zinc Ion Binding
Histone H3K14 Acetyltransferase Activity
Histone H4K5 Acetyltransferase Activity
Histone H4K8 Acetyltransferase Activity
Histone H4K12 Acetyltransferase Activity
Metal Ion Binding
Unmodified Histone Reader Activity
Histone Reader Activity
Biological Process
Autophagosome Assembly
Angiogenesis
Regulation Of Cytokine Production
Regulation Of Immune System Process
Proteolysis
Apoptotic Process
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Signal Transduction
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Processing
Natural Killer Cell Activation
Cell Differentiation
Macrophage Differentiation
Positive Regulation Of Cell Migration
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Response To Tumor Necrosis Factor
TRAIL-activated Apoptotic Signaling Pathway
T Cell Activation
B Cell Activation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Innate Immune Response
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Animal Organ Development
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptotic Inflammatory Response
Cellular Response To Mechanical Stimulus
Response To Anesthetic
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Self Proteolysis
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Response To Immobilization Stress
Erythrocyte Maturation
Positive Regulation Of Erythrocyte Differentiation
Regulation Of Developmental Process
Response To Electrical Stimulus
Regulation Of Hemopoiesis
Pathways
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Regulation of NF-kappa B signaling
HATs acetylate histones
Regulation of TP53 Activity through Acetylation
Drugs
Trichostatin A
AN-9
Bryostatin 1
Bardoxolone
Oleandrin
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Basal cell carcinoma (
33549134
25855136
28177523
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
23770605
26956414
28165464
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte count (
27863252
)
Melanoma (
28212542
21983787
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
Spleen volume (
34128465
)
White blood cell count (
32888494
)
Acne (severe) (
24927181
)
Heel bone mineral density x serum urate levels interaction (
34046847
)
Mean platelet volume (
27863252
)
Metabolite levels (
23823483
)
Natriuretic peptide levels (
21273288
)
Pulse pressure (
30224653
)
Schizophrenia (
23894747
)
Urinary albumin excretion (
32277301
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
133 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
OGT
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RNF31
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
17 interacting genes:
CASP8
CEP126
CEP70
DISC1
FEZ1
FEZ2
H2AX
H3C14
HMBOX1
MAGEA11
PICK1
RUBCN
SS18L1
TFIP11
VIM
ZNF512B
ZRANB1
Entrez ID
841
23774
HPRD ID
03459
06848
Ensembl ID
ENSG00000064012
ENSG00000100425
Uniprot IDs
A0A8Q3SID9
Q14790
O95696
Q59G93
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
7DEE
7LVJ
7LVM
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
2KU3
2L43
2LQ6
3LYI
3RCW
4Z02
5AME
5AMF
5FG6
5GK9
5N49
5PNX
5PNY
5PNZ
5PO0
5PO1
5PO2
5PO3
5PO4
5PO5
5PO6
5PO7
5PO8
5PO9
5POA
5POB
5POC
5POD
5POE
5POF
5POG
5POH
5POI
5POJ
5POK
5POL
5POM
5PON
5POO
5POP
5POQ
5POR
5POS
5POT
5POU
5POV
5POW
5POX
5POY
5POZ
5PP0
5PP1
5PP2
5PP3
5PP4
5PP5
5PP6
5PP7
5PP8
5PP9
5PPA
5PPB
5PPC
5PPD
5PPE
5PPF
5PPG
5PPH
5PPI
5PPJ
5PPK
5PPL
5PPM
5PPN
5PPO
5PPP
5PPQ
5PPR
5PPS
5PPT
5PPU
5PPV
5PPW
5PPX
5PPY
5PPZ
5PQ0
5PQ1
5PQ2
5PQ3
5PQ4
5PQ5
5PQ6
5PQ7
5PQ8
5PQ9
5PQA
5PQB
5PQC
5PQD
5PQE
5PQF
5PQG
5PQH
5PQI
5PQJ
5PQK
5PQL
5PQM
5PQN
5PQO
5PQP
5PQQ
5PQR
5PQS
5PQT
5PQU
5PQV
5PQW
5PQX
5PQY
5PQZ
5PR0
5PR1
5PR2
5PR4
5PR5
5PR6
5PR7
5PR8
5PR9
5PRA
5PRB
5PRD
5PRE
5PRF
5PRG
5PRH
5PRI
5PRJ
5PRK
5PRL
5PRM
5PRO
5PRP
5PRQ
5PRR
5PRS
5PRT
5PRU
5PRV
5PRW
5PRX
5PRY
5PRZ
5PS0
5PS1
5PS2
5PS3
5PS4
5PS5
5PS6
5PS7
5PS8
5PS9
5PSA
5PSB
5PSC
5PSD
5PSE
5PSF
5PSG
5PSH
5PSI
5PSJ
5PSK
5PSL
5PSM
5PSN
5PSO
5PSP
5PSQ
5PSR
5PSS
5PST
5PSU
5PSV
5PSW
5PSX
5PSY
5PSZ
5PT0
5PT1
5PT2
5PT3
5PT4
5PT5
5PT6
5PT7
5PT8
5PT9
5PTA
5PTB
5PTC
5PTE
5PTF
5PTG
5PTH
5PTJ
5PTK
5PTL
5PTM
5PTN
5PTO
5PTQ
5PTR
5PTS
5PTT
5PTU
5PTV
5PTW
5PTX
5PTY
5PTZ
5PU0
5PU1
5PU2
5PU3
5PU4
5PU5
5PU6
5PU7
5PU8
5PU9
5PUA
5PUB
5PUC
5PUD
5PUE
5PUF
5PUG
5PUH
5PUI
5PUJ
5PUK
5PUL
5PUM
5PUN
5PUO
5PUP
5PUQ
5PUR
5PUS
5PUT
5PUU
5PUV
5PUW
5PUX
5PUY
5PUZ
5PV0
5PV1
5PV2
5PV3
5PV4
5PV5
5PV6
5PV7
5PV8
5PV9
5PVA
5PVB
5PVC
5PVD
5PVE
5PVF
5PVG
5PVH
5PVI
5PVJ
5PVK
5PVL
5PVM
5PVN
5PVO
5PVP
5PVQ
5PVR
5PVS
5PVT
5PVU
5PVV
5PVW
5PVX
5PVY
5PVZ
5PW0
5PW1
5PW2
5PW3
5PW4
5PW5
5PW6
5PW7
5PW8
5PW9
5PWA
5PWB
6IN2
6MAJ
6MAK
7D0O
7D0P
7D0Q
7D0R
7D0S
7LH9
Enriched GO Terms of Interacting Partners
?
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Extrinsic Apoptotic Signaling Pathway
Signal Transduction
Negative Regulation Of Programmed Cell Death
Cellular Response To Stress
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Cytosol
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cytoplasm
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Oxygen-containing Compound
Ubiquitin Protein Ligase Binding
Intrinsic Apoptotic Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cysteine-type Endopeptidase Activity
Protein Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Programmed Necrotic Cell Death
Plasma Membrane Bounded Cell Projection Organization
Cell Projection Organization
Negative Regulation Of Macroautophagy
Centrosome
Negative Regulation Of Cellular Component Organization
Negative Regulation Of Autophagosome Assembly
Microtubule Organizing Center
Negative Regulation Of Autophagy
Regulation Of Cellular Component Organization
Organelle Organization
Cytoskeleton
Regulation Of Metabolic Process
Organelle Assembly
Negative Regulation Of Metabolic Process
Axon
Gamma-tubulin Binding
Cellular Component Assembly
Protein-DNA Complex Assembly
Chromosome, Telomeric Region
Neuron Projection Development
Regulation Of Neuron Projection Development
Intermediate Filament Cytoskeleton
Protein Kinase C Binding
Regulation Of Macroautophagy
Regulation Of Autophagosome Assembly
Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion
Ciliary Base
Telomere-telomerase Complex Assembly
Non-motile Cilium Assembly
Regulation Of Vacuole Organization
Glial Cell Development
Spliceosomal Complex Disassembly
Cilium Assembly
Scaffold Protein Binding
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Cell Body
Negative Regulation Of Autophagosome Maturation
U2-type Post-mRNA Release Spliceosomal Complex
Cilium Organization
Pyramidal Neuron Migration To Cerebral Cortex
Central Region Of Growth Cone
Structural Constituent Of Chromatin
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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