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APAF1 and CYCS
Number of citations of the paper that reports this interaction (PubMedID
16979168
)
0
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
APAF1
CYCS
Description
apoptotic peptidase activating factor 1
cytochrome c, somatic
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Secretory Granule Lumen
Apoptosome
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Nucleus
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Apoptosome
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Heat Shock Protein Binding
Identical Protein Binding
ADP Binding
Cysteine-type Endopeptidase Activator Activity
Protein Binding
Electron Transfer Activity
Heme Binding
Metal Ion Binding
Biological Process
Response To Hypoxia
Kidney Development
Neural Tube Closure
Apoptotic Process
Nervous System Development
Brain Development
Response To Nutrient
Cardiac Muscle Cell Apoptotic Process
Cell Differentiation
Forebrain Development
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
System Development
Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To G1 DNA Damage Checkpoint Signaling
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Apoptotic Signaling Pathway
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Apoptotic Process
Cellular Respiration
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Pathways
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Neutrophil degranulation
TP53 Regulates Transcription of Caspase Activators and Caspases
Transcriptional Regulation by E2F6
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
Pyroptosis
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Cytoprotection by HMOX1
Drugs
ATP
Minocycline
Protoporphyrin Ix Containing Co
Ferroheme C
Imidazole
Zinc protoporphyrin
Trimethyllysine
Zinc Substituted Heme C
Artenimol
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Alzheimer's disease (cognitive decline) (
23535033
)
High density lipoprotein cholesterol levels (
30498476
)
Systemic lupus erythematosus (
19838195
)
Interacting Genes
19 interacting genes:
APIP
AVEN
BCL2L1
BCL2L10
CASP3
CASP4
CASP8
CASP9
CYCS
FAS
FEM1B
HIP1
HSP90AA1
HSPA1A
NLRP1
NUP107
PPP1CA
TOP1
TRIAP1
22 interacting genes:
AGTPBP1
APAF1
BCL2
BCL2L1
CASP9
COX4I2
CUL9
CYB5A
CYB5R1
CYB5R3
CYC1
FDX1
HSPA8
HSPB1
KRT40
MEOX2
NDOR1
RNF7
SAFB
SNCA
UQCRC1
VDAC2
Entrez ID
317
54205
HPRD ID
03755
00479
Ensembl ID
ENSG00000120868
ENSG00000172115
Uniprot IDs
O14727
G4XXL9
P99999
PDB IDs
1C15
1CWW
1CY5
1Z6T
2P1H
2YGS
3J2T
3JBT
3YGS
4RHW
5JUY
5WVC
5WVE
8XQK
1J3S
2N3Y
2N9I
2N9J
3NWV
3ZCF
3ZOO
5EXQ
5O10
5TY3
6DUJ
6ECJ
6XNK
Enriched GO Terms of Interacting Partners
?
Cell Death
Programmed Cell Death
Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Pyroptotic Inflammatory Response
Intrinsic Apoptotic Signaling Pathway
Response To Anesthetic
Death-inducing Signaling Complex
Positive Regulation Of Pyroptotic Inflammatory Response
Response To Cobalt Ion
Mitochondrion
Leukocyte Apoptotic Process
Neuron Apoptotic Process
Positive Regulation Of Apoptotic Process
Death Receptor Binding
Positive Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Nucleus
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Apoptosome
Response To Radiation
Execution Phase Of Apoptosis
Positive Regulation Of Defense Response
Negative Regulation Of Programmed Cell Death
Response To Stress
Glial Cell Apoptotic Process
Cytosol
Inflammatory Response
CD95 Death-inducing Signaling Complex
NLRP1 Inflammasome Complex
Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Epithelial Cell Apoptotic Process
Regulation Of Neuron Apoptotic Process
Cysteine-type Peptidase Activity
Negative Regulation Of Apoptotic Process
Self Proteolysis
Response To UV
Fibroblast Apoptotic Process
Intracellular Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Maturation
Cellular Response To Radiation
Positive Regulation Of Inflammatory Response
Response To Light Stimulus
Interleukin-18-mediated Signaling Pathway
Electron Transport Chain
Mitochondrial Outer Membrane
Mitochondrion
Neuron Apoptotic Process
Generation Of Precursor Metabolites And Energy
Mitochondrial Membrane
Apoptosome
Dendritic Cell Apoptotic Process
Respiratory Electron Transport Chain
Mitochondrial Membrane Organization
Mitochondrion Organization
Quinol-cytochrome-c Reductase Activity
FAD Binding
BH3 Domain Binding
Cytochrome-b5 Reductase Activity, Acting On NAD(P)H
Epithelial Cell Apoptotic Process
Leukocyte Apoptotic Process
Negative Regulation Of Dendritic Cell Apoptotic Process
Regulation Of Mitochondrial Membrane Permeability
Bcl-2 Family Protein Complex
Electron Transfer Activity
Intrinsic Apoptotic Signaling Pathway
Respiratory Chain Complex III
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Apoptotic Mitochondrial Changes
Regulation Of Membrane Permeability
Pore Complex
Aerobic Electron Transport Chain
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Steroid Biosynthetic Process
Mitochondrial Inner Membrane
Response To Alkaloid
Platelet Alpha Granule Membrane
Aerobic Respiration
Negative Regulation Of Anoikis
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Autophagy
Programmed Cell Death Involved In Cell Development
Cellular Respiration
Oxidative Phosphorylation
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Cytosol
Positive Regulation Of Apoptotic Process
Regulation Of Anoikis
Ubiquitin Protein Ligase Binding
Sterol Metabolic Process
Protein Refolding
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
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Tagcloud (Intersection)
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