APAF1 and CASP8

  • Number of citations of the paper that reports this interaction (PMID 9539746)
  • 61
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo)

APAF1

CASP8

Gene Name apoptotic peptidase activating factor 1 caspase 8, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1 91 interactors: APAF1 APP AR ATG4D BCAP31 BCL2 BCL2L1 BFAR BID BIRC6 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CDH1 CDK11B CDKN1B CFLAR CHD3 CHUK COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 FADD FAF1 FAS FYN GMEB1 GRIA1 GZMB HDAC7 HECTD3 HIP1 IKBKB IKBKG ILK KRT18 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 PARK2 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PLA2G4B PLEC PLIN4 PRDX6 PRKCI PRKCZ PSEN1 PSEN2 RALBP1 RB1 RIPK1 RIPK2 RYBP SNRPD3 SRF STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 USO1 VIM
Entrez ID 317 841
HPRD ID 03755 03459
Ensembl ID ENSG00000120868 ENSG00000064012
Uniprot IDs O14727 Q14790
PDB IDs 1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS 1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
alleviate  amounts  angiogenesis  anthocyanins  bace2  brings  confirm  downregulate  downregulated  enriched  fruit  great  microarray  microarrays  modulated  mtt  mulberry  mumol  neuroprotection  neuroprotective  neutralize  nutrigenomics  pc12  peptidase  plcb4  preincubated  preincubation  pretreatment  substantially 
10mum  abeta42  abeta43  aif  carnosic  cascades  casp3  casp4  casp9  casps  concurrently  diterpene  herbs  ingestion  initiator  labiate  monomer  neurotoxicity  neurotrophic  oligomerization  oligomers  parp  phenolic  ribose  rosemary  sage  serves  sy5y 
Tagcloud (Difference) ?
alleviate  amounts  angiogenesis  anthocyanins  bace2  brings  confirm  downregulate  downregulated  enriched  fruit  great  microarray  microarrays  modulated  mtt  mulberry  mumol  neuroprotection  neuroprotective  neutralize  nutrigenomics  pc12  peptidase  plcb4  preincubated  preincubation  pretreatment  substantially 
10mum  abeta42  abeta43  aif  carnosic  cascades  casp3  casp4  casp9  casps  concurrently  diterpene  herbs  ingestion  initiator  labiate  monomer  neurotoxicity  neurotrophic  oligomerization  oligomers  parp  phenolic  ribose  rosemary  sage  serves  sy5y 
Tagcloud (Intersection) ?