APAF1 and TRIAP1

Number of citations of the paper that reports this interaction (PubMedID 15735003)
0

Data Source:
HPRD (in vivo, in vitro)

		APAF1	TRIAP1
Description		apoptotic peptidase activating factor 1	TP53 regulated inhibitor of apoptosis 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity	P53 Binding Protein Binding Phosphatidic Acid Transfer Activity
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Lipid Transport Apoptotic Process Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To UV Negative Regulation Of Apoptotic Process Phospholipid Translocation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Intermembrane Lipid Transfer Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Mitochondrial protein degradation
Drugs		ATP
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Immature fraction of reticulocytes ( 32888494) Insulin resistance/response ( 21901158) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1	6 interacting genes: AMY2A APAF1 HSPA1A LCN2 PLEKHF2 TP53
Entrez ID		317	51499
HPRD ID		03755	13698
Ensembl ID		ENSG00000120868	ENSG00000170855
Uniprot IDs		O14727	O43715
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK	4XZS 4XZV 6I3V 6I3Y 6I4Y 8AG0
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway	Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Disordered Domain Specific Binding Response To X-ray Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Heat Shock Protein Binding Response To Oxygen Levels Apoptotic Signaling Pathway Response To G1 DNA Damage Checkpoint Signaling Response To Decreased Oxygen Levels Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Response To Oxidative Stress Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Alpha-amylase Activity Carbohydrate Catabolic Process Positive Regulation Of Programmed Cell Death Apoptosome Response To Nutrient Levels Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Ficolin-1-rich Granule Lumen Denatured Protein Binding Lysosomal Transport Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrial Membrane Organization Regulation Of Mitochondrion Organization Histone Deacetylase Binding Positive Regulation Of Iron Ion Import Across Plasma Membrane Siderophore Transport Protease Binding Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate
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