APAF1 and PPP1CA

Number of citations of the paper that reports this interaction (PMID 17274640)
12

Data Source:
HPRD (in vitro, in vivo)

		APAF1	PPP1CA
Gene Name		apoptotic peptidase activating factor 1	protein phosphatase 1, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Glycogen Granule Dendritic Spine Perikaryon Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Lung Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis	Loss of Function of TGFBR2 in Cancer Signaling by GPCR TGFBR2 MSI Frameshift Mutants in Cancer Metabolism of lipids and lipoproteins SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Opioid Signalling TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis DARPP-32 events SMAD4 MH2 Domain Mutants in Cancer
Drugs		Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	148 interactors: AATK AKAP1 AKAP11 AKAP9 AKT1 APAF1 AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CASC5 CAV1 CCDC181 CD2BP2 CDC5L CDH1 CEP170 CKB CLCN2 CLTC CNP CNST CNTN1 CREB1 CRK CSNK1E CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 EED EIF2AK2 FRMPD4 FXYD1 GLIPR1L2 GLTSCR2 GPKOW H2AFX HEYL HSPA4 IBTK ID2 JPH3 KANK1 KCNQ1 KCTD20 KIAA1377 KIF13A KIF18A LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MIIP MPHOSPH10 MST1R MYO16 NCAM1 NDP NEK2 NOC2L NOM1 NONO PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R2P3 PPP1R2P9 PPP1R32 PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PREX1 PRKCB PRKCD PRR16 PTEN RANBP9 RB1 RIF1 RPRD2 SFPQ SFRP1 SH3RF2 SKP1 SLC45A1 SNCAIP SORL1 SPRED1 STAM STAU1 SYTL2 TCTEX1D4 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TUSC3 UBE2Z ULK1 VDR WBP11 WDR82 WWTR1 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827
Entrez ID		317	5499
HPRD ID		03755	15942
Ensembl ID		ENSG00000120868	ENSG00000172531
Uniprot IDs		O14727	P62136
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS	3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress	Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Dephosphorylation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Apoptotic Process Negative Regulation Of Dephosphorylation Regulation Of Cellular Component Organization Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Cell Death Negative Regulation Of Cellular Metabolic Process Death Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Cell Cycle Process Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Organelle Organization Intracellular Signal Transduction Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process Regulation Of Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Catalytic Activity Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Kinase Activity
Tagcloud ?		alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Difference) ?		alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Intersection) ?