APAF1 and ACADS

Data Source: HiPPIP (Novel)

		APAF1	ACADS
Name		apoptotic peptidase activating factor 1	acyl-CoA dehydrogenase short chain
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity	Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Short-chain Fatty Acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Butyrate Catabolic Process
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs		ATP	NADH Acetoacetyl-CoA Flavin adenine dinucleotide
Diseases		None	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 )	Allergic rhinitis ( 30013184 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Mean corpuscular volume ( 29403010 ) Metabolic traits ( 21886157 ) Metabolite levels ( 31628463 20037589 ) Red blood cell count ( 27863252 ) Red cell distribution width ( 27863252 ) Refractive error ( 32231278 ) Schizophrenia ( 30285260 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 ) Urinary metabolites (H-NMR features) ( 24586186 )
Novel Interactors		12 novel interactors: ACADS CCL13 CDK17 DZIP1 ELK3 HNF1A MRPL19 NR1H4 NUDT4 PAH RPL26L1 UTP20	1 novel interactors: APAF1
Interacting Genes		19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1	1 interacting genes: IRF7
Entrez ID		317	35
HPRD ID		03755	06053
Ensembl ID		ENSG00000120868	ENSG00000122971
Uniprot IDs		O14727	B4DUH1 E5KSD5 E9PE82 P16219
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK	2VIG 7Y0A 7Y0B 8SGS
GO Terms Enriched among Interactors		Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway	Response To G1 DNA Damage Checkpoint Signaling Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Apoptosome Response To DNA Damage Checkpoint Signaling Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Monocyte Differentiation Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interferon-alpha Production Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Myeloid Cell Apoptotic Process ADP Binding Immunoglobulin Mediated Immune Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Type I Interferon-mediated Signaling Pathway B Cell Mediated Immunity Type I Interferon-mediated Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Heat Shock Protein Binding Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Interferon-beta Production Positive Regulation Of Signal Transduction Forebrain Development Cellular Response To Stress Response To Transforming Growth Factor Beta Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Cell Communication Tube Closure Intracellular Signal Transduction Positive Regulation Of Signaling Neural Tube Closure Positive Regulation Of Type I Interferon Production Cis-regulatory Region Sequence-specific DNA Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Pattern Recognition Receptor Signaling Pathway Neuron Apoptotic Process