APAF1 and AVEN

Number of citations of the paper that reports this interaction (PubMedID 10949025)
0

Data Source:
HPRD (two hybrid, in vivo)

		APAF1	AVEN
Description		apoptotic peptidase activating factor 1	apoptosis and caspase activation inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Endomembrane System Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity	Protein Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Apoptotic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Apoptotic Process
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Formation of apoptosome Regulation of the apoptosome activity
Drugs		ATP
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Malaria ( 31844061)
Interacting Genes		19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1	4 interacting genes: APAF1 BCL2L1 SMURF1 UBC
Entrez ID		317	57099
HPRD ID		03755	05588
Ensembl ID		ENSG00000120868	ENSG00000169857
Uniprot IDs		O14727	Q9NQS1
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway	Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Mitochondrion Apoptotic Process In Bone Marrow Cell Engulfment Of Target By Autophagosome Mitochondrial Processing Peptidase Complex Apoptosome Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Protein Processing Involved In Protein Targeting To Mitochondrion Regulation Of Apoptotic DNA Fragmentation Response To DNA Damage Checkpoint Signaling Cysteine-type Endopeptidase Activator Activity Response To Cycloheximide Bcl-2 Family Protein Complex Negative Regulation Of Dendritic Cell Apoptotic Process BH3 Domain Binding Negative Regulation Of Execution Phase Of Apoptosis Mitochondrial Outer Membrane Proteolysis Mitochondrial Protein Processing Activin Receptor Binding Substrate Localization To Autophagosome Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Striated Muscle Cell Apoptotic Process Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Tag Activity Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Transforming Growth Factor Beta Receptor Binding Regulation Of Apoptotic Signaling Pathway Muscle Cell Apoptotic Process Hepatocyte Apoptotic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Ectopic Germ Cell Programmed Cell Death Mitochondrial Matrix Negative Regulation Of Anoikis I-SMAD Binding Negative Regulation Of Activin Receptor Signaling Pathway Receptor Catabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrial Inner Membrane Negative Regulation Of Membrane Permeability Positive Regulation Of Dendrite Extension
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