APAF1 and MRPL19

		APAF1	MRPL19
Description		apoptotic peptidase activating factor 1	mitochondrial ribosomal protein L19
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity	Structural Constituent Of Ribosome Protein Binding
	Biological Process	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Translation Mitochondrial Translation
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs		ATP
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)	Diabetic macular edema in type 2 diabetes ( 29739359) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1	8 interacting genes: APP LRRK2 MAGEC1 NEDD4 NEDD4L PRKN TRIM55 TRIM63
Entrez ID		317	9801
HPRD ID		03755	11370
Ensembl ID		ENSG00000120868	ENSG00000115364
Uniprot IDs		O14727	P49406
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIS 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway	Cellular Response To Manganese Ion Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Catabolic Process Response To Curcumin Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Neuromuscular Junction Development Ubiquitin Protein Ligase Activity Regulation Of Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Transport Positive Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Cellular Response To Dopamine Regulation Of Retrograde Transport, Endosome To Golgi Postsynapse Sodium Channel Inhibitor Activity Response To Dopamine Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Synapse Organization Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Synaptic Transmission, Glutamatergic Potassium Channel Inhibitor Activity Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Excitatory Postsynaptic Potential Protein Polyubiquitination Protein Ubiquitination Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Long-term Synaptic Potentiation Import Into Cell Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Synapse Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Endocytosis Regulation Of Cell Projection Organization Negative Regulation Of Sodium Ion Transport Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Response To Metal Ion
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