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CASP8
Gene Name
caspase 8, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Microtubule Organizing Center
Cytosol
Cytoskeleton
Noc1p-Noc2p Complex
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Ubiquitin Protein Ligase Binding
Protein Complex Binding
Death Effector Domain Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Biological Process
Angiogenesis
Neural Tube Formation
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Cold
Viral Process
Natural Killer Cell Activation
Macrophage Differentiation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Tumor Necrosis Factor
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
T Cell Activation
B Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Response To Antibiotic
Protein Heterooligomerization
Proteolysis Involved In Cellular Protein Catabolic Process
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Regulation Of Thymocyte Apoptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Response To Organic Cyclic Compound
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Activation Of Cysteine-type Endopeptidase Activity
Hepatocyte Apoptotic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
TRAIL signaling
Death Receptor Signalling
Caspase-8 activation by cleavage
FasL/ CD95L signaling
Activation, myristolyation of BID and translocation to mitochondria
Caspase-mediated cleavage of cytoskeletal proteins
Activated TLR4 signalling
NOD1/2 Signaling Pathway
Programmed Cell Death
TRIF-mediated programmed cell death
Innate Immune System
Intrinsic Pathway for Apoptosis
Regulation by c-FLIP
Apoptotic cleavage of cellular proteins
Dimerization of procaspase-8
TRIF-mediated TLR3/TLR4 signaling
Apoptotic execution phase
MyD88-independent cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Extrinsic Pathway
Drugs
Diseases
GWAS
Melanoma (
21983787
)
Protein-protein Interactions
91 interactors:
APAF1
APP
AR
ATG4D
BCAP31
BCL2
BCL2L1
BFAR
BID
BIRC6
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CDH1
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
FADD
FAF1
FAS
FYN
GMEB1
GRIA1
GZMB
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
ILK
KRT18
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
PARK2
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PLA2G4B
PLEC
PLIN4
PRDX6
PRKCI
PRKCZ
PSEN1
PSEN2
RALBP1
RB1
RIPK1
RIPK2
RYBP
SNRPD3
SRF
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
TRAF6
USO1
VIM
Entrez ID
841
HPRD ID
03459
Ensembl ID
ENSG00000064012
Uniprot IDs
Q14790
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
Enriched GO Terms of Interacting Partners
?
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cell Death
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Protein Processing
Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Peptidase Activity
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endopeptidase Activity
Regulation Of Cellular Protein Metabolic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity
Regulation Of Proteolysis
Regulation Of Endopeptidase Activity
Positive Regulation Of Cysteine-type Endopeptidase Activity
Zymogen Activation
Regulation Of Signal Transduction
Regulation Of Peptidase Activity
Cell Communication
Regulation Of Signaling
Positive Regulation Of Cellular Metabolic Process
Extrinsic Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway
Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Regulation Of Catalytic Activity
Signaling
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Response To Stress
Execution Phase Of Apoptosis
Negative Regulation Of Cell Death
Regulation Of Metabolic Process
Tagcloud
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10mum
abeta42
abeta43
aif
carnosic
cascades
casp3
casp4
casp9
casps
concurrently
diterpene
herbs
ingestion
initiator
labiate
monomer
neurotoxicity
neurotrophic
oligomerization
oligomers
parp
phenolic
ribose
rosemary
sage
serves
sy5y