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CASP8 and ATAD2
Number of citations of the paper that reports this interaction (PubMedID
25640309
)
0
Data Source:
BioGRID
(two hybrid)
CASP8
ATAD2
Description
caspase 8
ATPase family AAA domain containing 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Cell Projection
Cell Body
Ripoptosome
Nucleus
Nucleoplasm
Extracellular Exosome
Molecular Function
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Nucleotide Binding
Chromatin Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Histone Binding
Biological Process
Autophagosome Assembly
Angiogenesis
Regulation Of Cytokine Production
Regulation Of Immune System Process
Proteolysis
Apoptotic Process
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Signal Transduction
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Processing
Natural Killer Cell Activation
Cell Differentiation
Macrophage Differentiation
Positive Regulation Of Cell Migration
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Response To Tumor Necrosis Factor
TRAIL-activated Apoptotic Signaling Pathway
T Cell Activation
B Cell Activation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Innate Immune Response
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Animal Organ Development
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptotic Inflammatory Response
Cellular Response To Mechanical Stimulus
Response To Anesthetic
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Self Proteolysis
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Nucleosome Assembly
Nucleosome Disassembly
Transcription Initiation-coupled Chromatin Remodeling
Positive Regulation Of DNA-templated Transcription
Pathways
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Regulation of NF-kappa B signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs
Trichostatin A
AN-9
Bryostatin 1
Bardoxolone
Oleandrin
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Basal cell carcinoma (
33549134
25855136
28177523
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
23770605
26956414
28165464
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte count (
27863252
)
Melanoma (
28212542
21983787
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
Spleen volume (
34128465
)
White blood cell count (
32888494
)
Interacting Genes
133 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
OGT
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RNF31
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
12 interacting genes:
BAG4
BCAR3
CASP8
E2F1
E2F2
E2F3
E2F4
ESR1
H3-4
H4C14
MYC
NCOA3
Entrez ID
841
29028
HPRD ID
03459
10678
Ensembl ID
ENSG00000064012
ENSG00000156802
Uniprot IDs
A0A8Q3SID9
Q14790
Q6PL18
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
7DEE
7LVJ
7LVM
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
3DAI
4QSP
4QSQ
4QSR
4QSS
4QST
4QSU
4QSV
4QSW
4QSX
4QUT
4QUU
4TT2
4TT4
4TT6
4TTE
4TU4
4TU6
4TYL
4TZ2
4TZ8
5A5N
5A5O
5A5P
5A5Q
5A5R
5A81
5A82
5A83
5EPB
5F36
5F3A
5LJ0
5QXI
5QXJ
5QXK
5QXL
5QXM
5QXN
5QXO
5QXP
5QXQ
5QXR
5QXS
5QXT
5QXU
5QXV
5QXW
5QXX
5QXY
5QXZ
5QY0
5R4E
5R4F
5R4V
5R4W
5R4X
5R4Y
5R4Z
6CPS
6EPJ
6EPR
6EPS
6EPT
6EPU
6EPV
6EPW
6EPX
6HDN
6HDO
6HI3
6HI4
6HI5
6HI6
6HI7
6HI8
6HIA
6HIB
6HIC
6HID
6HIE
6S55
6S56
6S57
6YB4
7M98
7PPX
7PX5
7Q6T
7Q6U
7Q6V
7Q6W
7QU7
7QUK
7QUM
7QWO
7QX1
7QXT
7QYK
7QYL
7QZM
7QZY
7QZZ
7R00
7R05
7R0Y
7Z9H
7Z9I
7Z9J
7Z9N
7Z9O
7Z9S
7Z9U
8H3H
8JUW
8JUY
8JUZ
8RU5
8SDO
8SDQ
Enriched GO Terms of Interacting Partners
?
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Extrinsic Apoptotic Signaling Pathway
Signal Transduction
Negative Regulation Of Programmed Cell Death
Cellular Response To Stress
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Cytosol
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cytoplasm
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Oxygen-containing Compound
Ubiquitin Protein Ligase Binding
Intrinsic Apoptotic Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cysteine-type Endopeptidase Activity
Protein Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Programmed Necrotic Cell Death
Protein Dimerization Activity
Cis-regulatory Region Sequence-specific DNA Binding
Transcription Regulator Complex
DNA-binding Transcription Activator Activity
RNA Polymerase II Transcription Regulator Complex
Chromatin
DNA-binding Transcription Factor Activity
Lens Fiber Cell Apoptotic Process
Negative Regulation Of Fat Cell Proliferation
Rb-E2F Complex
Protein-containing Complex
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Regulation Of Fibroblast Proliferation
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Developmental Process
Chromatin Remodeling
Apoptotic Signaling Pathway
Response To Estradiol
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Chromatin Organization
Regulation Of Apoptotic Process
Regulation Of Multicellular Organismal Development
Nucleoplasm
Nucleobase-containing Compound Biosynthetic Process
Sequence-specific DNA Binding
Intrinsic Apoptotic Signaling Pathway
Regulation Of Programmed Cell Death
Positive Regulation Of Cell Population Proliferation
Protein-DNA Complex Assembly
Cellular Response To Estradiol Stimulus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Smooth Muscle Cell Apoptotic Process
Regulation Of Cell Differentiation
Positive Regulation Of Apoptotic Process
Transcription Coregulator Binding
Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Programmed Cell Death
Regulation Of Cell Population Proliferation
Epithelial Cell Apoptotic Process
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