APAF1 and BCL2L10

Number of citations of the paper that reports this interaction (PMID 9878060)
28

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		APAF1	BCL2L10
Gene Name		apoptotic peptidase activating factor 1	BCL2-like 10 (apoptosis facilitator)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Apoptosome Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding ADP Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Neural Tube Closure Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nervous System Development Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Response To G1 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Female Gamete Generation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome Apoptotic factor-mediated response Programmed Cell Death Cytochrome c-mediated apoptotic response Intrinsic Pathway for Apoptosis
Drugs		Adenosine triphosphate Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 PPP1CA TOP1 TRIAP1	7 interactors: APAF1 BAD BAK1 BAX BCL2 BCL2L1 NR4A1
Entrez ID		317	10017
HPRD ID		03755	06071
Ensembl ID		ENSG00000120868	ENSG00000137875
Uniprot IDs		O14727	H0YMD5 Q9HD36
PDB IDs		1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3YGS	4B4S
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Programmed Cell Death Protein Processing Positive Regulation Of Cell Death Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Neuron Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Death Negative Regulation Of Apoptotic Process Hepatocyte Apoptotic Process Regulation Of Catalytic Activity Execution Phase Of Apoptosis Positive Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress	Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Positive Regulation Of Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Mitochondrial Transport Programmed Cell Death Cell Death Death Response To Gamma Radiation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Neuron Death Regulation Of Protein Heterodimerization Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Apoptotic Process Regulation Of Membrane Potential Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Protein Homodimerization Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intracellular Signal Transduction Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Mitochondrion Organization Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Ionizing Radiation Positive Regulation Of Peptidase Activity
Tagcloud ?		alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	affects agent approved cda common continued cr dck decitabine determine furthermore hent1 indicate induce level marrow mds measured mechanisms metabolic metabolism mrna regulated relapse resistance response secondary therapeutic underlying
Tagcloud (Difference) ?		alleviate amounts angiogenesis anthocyanins bace2 brings confirm downregulate downregulated enriched fruit great microarray microarrays modulated mtt mulberry mumol neuroprotection neuroprotective neutralize nutrigenomics pc12 peptidase plcb4 preincubated preincubation pretreatment substantially	affects agent approved cda common continued cr dck decitabine determine furthermore hent1 indicate induce level marrow mds measured mechanisms metabolic metabolism mrna regulated relapse resistance response secondary therapeutic underlying
Tagcloud (Intersection) ?