CASP8 and STK24

Number of citations: 0 (PubMedID 12107159)
Data Source: HPRD (in vivo, in vitro)

		CASP8	STK24
Name		caspase 8	serine/threonine kinase 24
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Lamellipodium Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Projection Cell Body Ripoptosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Exosome FAR/SIN/STRIPAK Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Angiogenesis Regulation Of Cytokine Production Regulation Of Immune System Process Proteolysis Apoptotic Process Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Processing Natural Killer Cell Activation Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Response To Tumor Necrosis Factor TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Regulation Of Apoptotic Process Chordate Embryonic Development Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Animal Organ Development Proteolysis Involved In Protein Catabolic Process Protein Maturation Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptotic Inflammatory Response Cellular Response To Mechanical Stimulus Response To Anesthetic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Self Proteolysis Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis	Protein Phosphorylation Apoptotic Process Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Starvation Negative Regulation Of Cell Migration Cellular Response To Oxidative Stress Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Axon Regeneration Execution Phase Of Apoptosis
Pathways		Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	Apoptotic cleavage of cellular proteins Apoptotic execution phase
Drugs		Trichostatin A AN-9 Bryostatin 1 Bardoxolone Oleandrin	Fostamatinib
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	None
GWAS		Basal cell carcinoma ( 33549134 25855136 28177523 ) Breast cancer ( 29059683 ) Chronic lymphocytic leukemia ( 23770605 26956414 28165464 ) Cutaneous malignant melanoma ( 32341527 ) Esophageal squamous cell carcinoma ( 25129146 ) Lymphocyte count ( 27863252 ) Melanoma ( 28212542 21983787 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of white cells ( 32888494 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Non-small cell lung cancer ( 31326317 ) Plateletcrit ( 32888494 ) Prostate cancer ( 29892016 ) Rheumatoid arthritis ( 30423114 24390342 ) Spleen volume ( 34128465 ) White blood cell count ( 32888494 )	Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Alzheimer's disease ( 22159054 ) Educational attainment ( 23722424 25201988 ) Gastroesophageal reflux disease ( 34187846 ) General factor of neuroticism ( 30867560 ) General risk tolerance (MTAG) ( 30643258 ) Household income (MTAG) ( 31844048 ) Longevity ( 20834067 ) Methadone dose in opioid dependence ( 28115739 ) Mood instability ( 31168069 ) Reading disability or specific language impairment (pleiotropy) ( 25065397 ) Shoulder impingement or rotator cuff tear ( 33482370 ) Triglyceride levels ( 32203549 ) Urinary sodium excretion ( 31409800 )
Interacting Genes		133 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 OGT PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RNF31 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707	12 interacting genes: CAB39 CASP3 CASP7 CASP8 ERBB2 LRRK2 NEDD4 OGT PDCD10 STK11 STK38L VAV2
Entrez ID		841	8428
HPRD ID		03459	10385
Ensembl ID		ENSG00000064012	ENSG00000102572
Uniprot IDs		A0A8Q3SID9 Q14790	B4DR80 Q5U0E6 Q6P0Y1 Q9Y6E0
PDB IDs		1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9 7DEE 7LVJ 7LVM 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN	3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA 4QO9 4U8Z 4W8D 4W8E 7B30 7B31 7B32 7B33 7B34 7B35 8BZI 8BZJ 8QLQ 8QLR 8QLS 8QLT
GO Terms Enriched among Interactors		Programmed Cell Death Cell Death Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Extrinsic Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Stress Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Cytosol Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Signaling Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Oxygen-containing Compound Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Cysteine-type Endopeptidase Activity Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Programmed Necrotic Cell Death	Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Pyroptotic Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Execution Phase Of Apoptosis Regulation Of Intracellular Signal Transduction Regulation Of Cellular Localization Cytosol Regulation Of Protein Metabolic Process Signal Transduction Neuromuscular Junction Development Protein Modification Process Cellular Response To Staurosporine Response To UV Regulation Of Autophagy Protein Processing Response To Anesthetic Death-inducing Signaling Complex Cysteine-type Endopeptidase Activity Positive Regulation Of Neuron Apoptotic Process Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response Protein Metabolic Process Cell Death Regulation Of Programmed Cell Death Programmed Cell Death Response To Cobalt Ion Cytoplasm Regulation Of Signal Transduction Fibroblast Apoptotic Process Regulation Of Intracellular Transport Heart Development Response To Stress Cell Projection Organization Protein Localization To Organelle Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Modification Process Golgi Localization Protein Maturation Response To Light Stimulus Apoptotic Signaling Pathway Response To Metal Ion Death Receptor Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Poly-ADP-ribosylation