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APAF1 and CASP9
Number of citations of the paper that reports this interaction (PubMedID
9922454
)
66
Data Source:
HPRD
(in vitro, in vivo)
APAF1
CASP9
Description
apoptotic peptidase activating factor 1
caspase 9
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Secretory Granule Lumen
Apoptosome
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Caspase Complex
Protein-containing Complex
Apoptosome
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Heat Shock Protein Binding
Identical Protein Binding
ADP Binding
Cysteine-type Endopeptidase Activator Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Activator Activity
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Protein Kinase Binding
Identical Protein Binding
Biological Process
Response To Hypoxia
Kidney Development
Neural Tube Closure
Apoptotic Process
Nervous System Development
Brain Development
Response To Nutrient
Cardiac Muscle Cell Apoptotic Process
Cell Differentiation
Forebrain Development
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
System Development
Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To G1 DNA Damage Checkpoint Signaling
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Apoptotic Signaling Pathway
Response To Hypoxia
Kidney Development
Response To Ischemia
Proteolysis
Apoptotic Process
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Protein Processing
Platelet Formation
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Cellular Response To UV
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Neuron Apoptotic Process
Protein Maturation
Cellular Response To Dexamethasone Stimulus
Response To Indole-3-methanol
Leukocyte Apoptotic Process
Response To Anesthetic
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Execution Phase Of Apoptosis
Epithelial Cell Apoptotic Process
Pathways
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Neutrophil degranulation
TP53 Regulates Transcription of Caspase Activators and Caspases
Transcriptional Regulation by E2F6
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
Caspase activation via Dependence Receptors in the absence of ligand
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
ATP
Pamidronic acid
Diseases
GWAS
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Alcoholic chronic pancreatitis (
28754779
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (creatinine) (
26831199
28452372
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) (
33937227
)
Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) (
33937227
)
Serum metabolite levels (
33031748
)
Urate levels (
31578528
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Interacting Genes
19 interacting genes:
APIP
AVEN
BCL2L1
BCL2L10
CASP3
CASP4
CASP8
CASP9
CYCS
FAS
FEM1B
HIP1
HSP90AA1
HSPA1A
NLRP1
NUP107
PPP1CA
TOP1
TRIAP1
47 interacting genes:
ABL1
AKT1
APAF1
ARNT
BCL10
BCL2L1
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BIRC8
CAPN2
CARD8
CASP10
CASP12
CASP3
CASP7
CASP8
CYCS
DCC
DIABLO
DSP
GMEB1
GZMB
HECTD3
HIP1
HSD17B4
HSPD1
ILK
JUN
LYN
MAP2K1
MAP2K2
MAPK1
MAPK3
MSTO1
MZB1
NAIP
NLRP1
NOD1
PRKCZ
RB1
RNF2
SRF
VIM
XIAP
Entrez ID
317
842
HPRD ID
03755
03756
Ensembl ID
ENSG00000120868
ENSG00000132906
Uniprot IDs
O14727
F8VVS7
P55211
PDB IDs
1C15
1CWW
1CY5
1Z6T
2P1H
2YGS
3J2T
3JBT
3YGS
4RHW
5JUY
5WVC
5WVE
8XQK
1JXQ
1NW9
2AR9
3D9T
3V3K
3YGS
4RHW
5JUY
5WVC
5WVE
Enriched GO Terms of Interacting Partners
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Cell Death
Programmed Cell Death
Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Signaling Pathway
Pyroptotic Inflammatory Response
Intrinsic Apoptotic Signaling Pathway
Response To Anesthetic
Death-inducing Signaling Complex
Positive Regulation Of Pyroptotic Inflammatory Response
Response To Cobalt Ion
Mitochondrion
Leukocyte Apoptotic Process
Neuron Apoptotic Process
Positive Regulation Of Apoptotic Process
Death Receptor Binding
Positive Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Activity
Nucleus
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Apoptosome
Response To Radiation
Execution Phase Of Apoptosis
Positive Regulation Of Defense Response
Negative Regulation Of Programmed Cell Death
Response To Stress
Glial Cell Apoptotic Process
Cytosol
Inflammatory Response
CD95 Death-inducing Signaling Complex
NLRP1 Inflammasome Complex
Extrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Epithelial Cell Apoptotic Process
Regulation Of Neuron Apoptotic Process
Cysteine-type Peptidase Activity
Negative Regulation Of Apoptotic Process
Self Proteolysis
Response To UV
Fibroblast Apoptotic Process
Intracellular Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Maturation
Cellular Response To Radiation
Positive Regulation Of Inflammatory Response
Response To Light Stimulus
Interleukin-18-mediated Signaling Pathway
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Regulation Of Cell Communication
Regulation Of Signaling
Execution Phase Of Apoptosis
Positive Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytoplasm
Regulation Of Defense Response
Regulation Of Inflammatory Response
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Defense Response
Neuron Apoptotic Process
Pyroptotic Inflammatory Response
Bergmann Glial Cell Differentiation
Regulation Of Golgi Inheritance
Negative Regulation Of Apoptotic Process
Cytosol
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Immune System Process
Regulation Of Immune Response
Cysteine-type Endopeptidase Inhibitor Activity
Glial Cell Development
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Protein Modification Process
Schwann Cell Development
Regulation Of Neuron Apoptotic Process
Trachea Formation
Response To Lipid
Regulation Of Innate Immune Response
Regulation Of Metabolic Process
Face Development
Positive Regulation Of Biosynthetic Process
Thymus Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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