AXIN2 and CSNK1E

Number of citations of the paper that reports this interaction (PMID 12183362)
51

Data Source:
HPRD (in vivo)

		AXIN2	CSNK1E
Gene Name		axin 2	casein kinase 1, epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell Cortex Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Beta-catenin Destruction Complex	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	GTPase Activator Activity Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Armadillo Repeat Domain Binding I-SMAD Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Proliferation Negative Regulation Of Cell Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Negative Regulation Of Catenin Import Into Nucleus Termination Of G-protein Coupled Receptor Signaling Pathway Odontogenesis Positive Regulation Of GTPase Activity Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Organic Cyclic Compound Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters Signaling by WNT in cancer	Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANKRD6 APC APC2 CSNK1E CTNNB1 GSK3B SMAD3	40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227
Entrez ID		8313	1454
HPRD ID		04935	02919
Ensembl ID		ENSG00000168646	ENSG00000213923
Uniprot IDs		E7ES00 Q9Y2T1	B0QY34 P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Process Regulation Of Cell Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Phosphorylation Positive Regulation Of Protein Catabolic Process Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Proteolysis Positive Regulation Of Stem Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Proteolysis Regulation Of Protein Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Chromosome Segregation Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Osteoblast Differentiation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Cell Development	Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod
Tagcloud ?		apposition bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt wnt16 wt	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Difference) ?		apposition bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt wnt16 wt	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Intersection) ?