CSNK1E and FAM83D

Number of citations of the paper that reports this interaction (PubMedID 36736316)
80

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		CSNK1E	FAM83D
Description		casein kinase 1 epsilon	family with sequence similarity 83 member D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex	Spindle Pole Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding
	Biological Process	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway	Epithelial To Mesenchymal Transition Signal Transduction Cell Population Proliferation Cell Migration Regulation Of TOR Signaling Regulation Of Protein Catabolic Process Cell Division Metaphase Chromosome Alignment Regulation Of ERK1 And ERK2 Cascade Protein Localization To Mitotic Spindle Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Signaling by EGFR
Drugs		Seliciclib Umbralisib
Diseases
GWAS		Keratoconus ( 31855235) Mastocytosis ( 32752121)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Huntington's disease progression ( 28642124)
Interacting Genes		61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618	5 interacting genes: CSNK1E DYNC1I1 GADD45A GSK3B PRMT1
Entrez ID		1454	81610
HPRD ID		02919	12744
Ensembl ID		ENSG00000213923	ENSG00000101447
Uniprot IDs		P49674 Q5U045	Q9H4H8
PDB IDs		4HNI 4HOK	5E0L 5E0M
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription	Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Positive Regulation Of P38MAPK Cascade Viral Protein Processing Regulation Of P38MAPK Cascade Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm DNA Repair Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Negative Regulation Of TOR Signaling Superior Temporal Gyrus Development TOR Signaling Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome GATOR1 Complex Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Cytoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Circadian Rhythm Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of JNK Cascade Negative Regulation Of Protein Metabolic Process Perinuclear Region Of Cytoplasm Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of TOR Signaling Negative Regulation Of TORC2 Signaling Positive Regulation Of Translation Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity Viral Process Protein-arginine Omega-N Monomethyltransferase Activity N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Centriole-centriole Cohesion Positive Regulation Of Proteolysis DNA Metabolic Process Regulation Of Signal Transduction
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