AXIN2 and ANKRD6

Number of citations of the paper that reports this interaction (PMID 12183362)
51

Data Source:
HPRD (in vivo, two hybrid)

		AXIN2	ANKRD6
Gene Name		axin 2	ankyrin repeat domain 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell Cortex Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Beta-catenin Destruction Complex	Nucleus Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Armadillo Repeat Domain Binding I-SMAD Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Proliferation Negative Regulation Of Cell Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Negative Regulation Of Catenin Import Into Nucleus Termination Of G-protein Coupled Receptor Signaling Pathway Odontogenesis Positive Regulation Of GTPase Activity Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Organic Cyclic Compound Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters Signaling by WNT in cancer
Drugs
Diseases
GWAS			vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		7 interactors: ANKRD6 APC APC2 CSNK1E CTNNB1 GSK3B SMAD3	2 interactors: AXIN2 CSNK1E
Entrez ID		8313	22881
HPRD ID		04935	09798
Ensembl ID		ENSG00000168646	ENSG00000135299
Uniprot IDs		E7ES00 Q9Y2T1	B7Z3D2 Q9Y2G4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Process Regulation Of Cell Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Phosphorylation Positive Regulation Of Protein Catabolic Process Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Proteolysis Positive Regulation Of Stem Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Proteolysis Regulation Of Protein Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Chromosome Segregation Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Osteoblast Differentiation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Cell Development	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Mismatch Repair Regulation Of Wnt Signaling Pathway Maintenance Of DNA Repeat Elements Regulation Of Cell Morphogenesis Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Centromeric Sister Chromatid Cohesion Intramembranous Ossification Negative Regulation Of Catenin Import Into Nucleus Regulation Of Sister Chromatid Cohesion Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Heart Formation Specification Of Organ Identity Regulation Of Catenin Import Into Nucleus DNA Metabolic Process Dorsal/ventral Axis Specification Negative Regulation Of Signal Transduction MRNA Stabilization Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Signal Transduction Cellular Protein Localization Bone Mineralization Negative Regulation Of Osteoblast Differentiation Organ Formation Regulation Of MRNA Stability Positive Regulation Of Stem Cell Differentiation Regulation Of RNA Stability Regulation Of Epithelial To Mesenchymal Transition Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of DNA Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Biomineral Tissue Development Negative Regulation Of Ossification Circadian Regulation Of Gene Expression Protein Localization Regulation Of Chromosome Segregation
Tagcloud ?		apposition bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt wnt16 wt	analogous asymmetrically canonical consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates wnt
Tagcloud (Difference) ?		apposition bending bf bfr bones compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt16 wt	analogous asymmetrically consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates
Tagcloud (Intersection) ?		canonical wnt