CSNK1E and TAZ

Number of citations of the paper that reports this interaction (PMID 20858893)
27

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CSNK1E	TAZ
Gene Name		casein kinase 1, epsilon	tafazzin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Intrinsic Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway	Phospholipid Metabolic Process Muscle Contraction Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Cardiac Muscle Tissue Development Cardiac Muscle Contraction
Pathways		Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes	Acyl chain remodeling of CL Metabolism of lipids and lipoproteins Mitochondrial protein import Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227	9 interactors: BTRC CHGB CSNK1E GSK3B LATS1 LATS2 RUNX1 SLC9A3R2 YWHAE
Entrez ID		1454	6901
HPRD ID		02919	02316
Ensembl ID		ENSG00000213923	ENSG00000102125
Uniprot IDs		B0QY34 P49674 Q5U045	Q16635
PDB IDs		4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Hippo Signaling Regulation Of Signaling Cell Cycle Process Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Circadian Rhythm Cellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Response To Organic Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Proteolysis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Heat Skin Development Negative Regulation Of Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermis Development Wnt Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Organ Development Tissue Development Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Rhythmic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Protein Localization Positive Regulation Of Mitochondrion Organization Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process
Tagcloud ?		accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Difference) ?		accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Intersection) ?