CSNK1E and RAD17

Number of citations of the paper that reports this interaction (PubMedID 31353086)
0

Data Source:
BioGRID (enzymatic study)

		CSNK1E	RAD17
Description		casein kinase 1 epsilon	RAD17 checkpoint clamp loader component
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Rad17 RFC-like Complex Site Of Double-strand Break
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding Chromatin-protein Adaptor Activity
	Biological Process	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of DNA Replication Mitotic Intra-S DNA Damage Checkpoint Signaling Mitotic DNA Replication Checkpoint Signaling Regulation Of Phosphorylation Protein Localization To Site Of Double-strand Break
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs		Seliciclib Umbralisib
Diseases
GWAS		Keratoconus ( 31855235) Mastocytosis ( 32752121)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618	20 interacting genes: ATM ATR CLSPN CSNK1E CSNK2A1 CSNK2B HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SMG7 SNU13 USP20
Entrez ID		1454	5884
HPRD ID		02919	09124
Ensembl ID		ENSG00000213923	ENSG00000152942
Uniprot IDs		P49674 Q5U045	A0A0G2JP78 O75943
PDB IDs		4HNI 4HOK	7Z6H 8GNN
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription	DNA Repair DNA Metabolic Process DNA Damage Response DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Checkpoint Clamp Complex Negative Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Macromolecule Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Mitotic DNA Integrity Checkpoint Signaling Response To Ionizing Radiation Regulation Of Cell Cycle Phase Transition Histone H2AXS139 Kinase Activity DNA Strand Elongation Involved In DNA Replication Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Single-stranded DNA Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation DNA Replication Factor C Complex DNA Replication Cellular Response To Radiation Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Process DNA Clamp Loader Activity Positive Regulation Of DNA-directed DNA Polymerase Activity Double-strand Break Repair DNA-templated DNA Replication Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Homologous Recombination Nucleus Response To Radiation Recombinational Repair Positive Regulation Of DNA Metabolic Process Mitotic Intra-S DNA Damage Checkpoint Signaling Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Telomerase Catalytic Core Complex Assembly Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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