CSNK1E and ZMYND8

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CSNK1E	ZMYND8
Description		casein kinase 1 epsilon	zinc finger MYND-type containing 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Dendritic Spine Dendritic Shaft Site Of DNA Damage
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding Histone H3K14ac Reader Activity Histone H3K4me1 Reader Activity DNA-binding Transcription Factor Binding
	Biological Process	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Chromatin Organization Regulation Of DNA-templated Transcription Nervous System Development Negative Regulation Of Cell Migration Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Filopodium Assembly Positive Regulation Of Dendritic Spine Development Protein Localization To Chromatin Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Density Protein 95 Clustering Positive Regulation Of Dendritic Spine Maintenance
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Seliciclib Umbralisib
Diseases
GWAS		Keratoconus ( 31855235) Mastocytosis ( 32752121)	Bipolar disorder ( 34099189) Caffeine consumption from coffee ( 33287642) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Migraine ( 27182965) Parahippocampal gyrus volume ( 31530798) Platelet distribution width ( 32888494) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618	17 interacting genes: ATN1 ATRX CSNK1E ERBB2 FHOD1 FMR1 FXR2 MEOX2 PBXIP1 PRKCB RERE SPOP SUMO2 USP7 WDR4 ZBTB7A ZFYVE9
Entrez ID		1454	23613
HPRD ID		02919	10166
Ensembl ID		ENSG00000213923	ENSG00000101040
Uniprot IDs		P49674 Q5U045	A0A087WVZ6 A6H8Y8 Q2HXV5 Q569J9 Q9ULU4
PDB IDs		4HNI 4HOK	4COS 5B73 5MQ4 5Y1Z 7CWH
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription	Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Proteasomal Protein Catabolic Process DNA Damage Response Chromatin Organization DNA Repair Translation Regulator Activity Transcription Coactivator Activity PML Body Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Androgen Receptor Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Presynaptic Cytosol Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Translation Negative Regulation Of Metabolic Process DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Transport Of Viral Material Gene Expression Involved In Extracellular Matrix Organization
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