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CSNK1E and PER1
Number of citations of the paper that reports this interaction (PubMedID
10848614
)
62
Data Source:
HPRD
(in vitro, in vivo)
CSNK1E
PER1
Description
casein kinase 1 epsilon
period circadian regulator 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Growth Cone
Neuronal Cell Body
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
Protein Binding
Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
E-box Binding
DNA-binding Transcription Factor Binding
Biological Process
DNA Repair
Protein Phosphorylation
Endocytosis
Signal Transduction
Intracellular Protein Localization
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Circadian Regulation Of Gene Expression
Non-canonical Wnt Signaling Pathway
Regulation Of Circadian Rhythm
Rhythmic Process
Circadian Behavior
Negative Regulation Of Small GTPase Mediated Signal Transduction
Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Amyloid-beta Formation
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Sodium Ion Transport
Chromatin Remodeling
Circadian Rhythm
Entrainment Of Circadian Clock
Post-transcriptional Regulation Of Gene Expression
Circadian Regulation Of Gene Expression
Regulation Of Hair Cycle
Regulation Of Circadian Rhythm
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Rhythmic Process
Response To CAMP
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of P38MAPK Cascade
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
AURKA Activation by TPX2
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Drugs
Seliciclib
Umbralisib
Diseases
GWAS
Keratoconus (
31855235
)
Mastocytosis (
32752121
)
HDL cholesterol levels (
32203549
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Interacting Genes
61 interacting genes:
AKAP17A
AKAP9
ANKRD6
APC
APP
ARHGEF1
AXIN1
AXIN2
BBS10
BHLHE41
BID
BMAL1
CADM4
CCDC14
CLOCK
CRY1
CSNK2B
DELEC1
DVL1
DVL2
DVL3
ENTR1
FAM110A
FAM110C
FAM83D
FBP1
FBXO7
FBXW11
GTF3C1
HAUS7
HES1
KAT7
NCOA3
NR1D2
PER1
PER2
PER3
PPP1CA
PPP1CC
PPP1R14A
PPP2R5D
PPP2R5E
PTPRD
RAD17
RAD54B
RBX1
RORA
RORC
SNCA
SOCS3
TAFAZZIN
TAOK1
TLE5
TNS2
TRIM2
TRIM3
WDCP
YAP1
ZMYND8
ZNF227
ZNF618
19 interacting genes:
CCDC57
CRY1
CRY2
CSNK1D
CSNK1E
CSNK1G2
CSNK2B
DELEC1
GPRASP1
HIF1A
LTB4R2
PER2
PER3
PNMA1
RBPMS
RIPOR2
TIMELESS
TNS2
TRIP6
Entrez ID
1454
5187
HPRD ID
02919
03774
Ensembl ID
ENSG00000213923
ENSG00000179094
Uniprot IDs
P49674
Q5U045
O15534
PDB IDs
4HNI
4HOK
Enriched GO Terms of Interacting Partners
?
Circadian Regulation Of Gene Expression
Regulation Of Circadian Rhythm
Circadian Rhythm
Regulation Of Signal Transduction
Rhythmic Process
Photoperiodism
Regulation Of Cell Communication
Regulation Of Signaling
Entrainment Of Circadian Clock By Photoperiod
Negative Regulation Of Signal Transduction
Entrainment Of Circadian Clock
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Response To Radiation
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Positive Regulation Of Circadian Rhythm
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Wnt Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
E-box Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Cycle
Response To Light Stimulus
Regulation Of Wnt Signaling Pathway
Regulation Of Primary Metabolic Process
Cytoplasm
Signal Transduction
Regulation Of Fat Cell Differentiation
Intracellular Signal Transduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Intracellular Signal Transduction
Transcription Corepressor Binding
Proteasomal Protein Catabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Canonical Wnt Signaling Pathway
Beta-catenin Binding
Positive Regulation Of Neuron Projection Arborization
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Circadian Rhythm
Circadian Regulation Of Gene Expression
Circadian Rhythm
Rhythmic Process
Entrainment Of Circadian Clock By Photoperiod
Photoperiodism
Entrainment Of Circadian Clock
Kinase Binding
Negative Regulation Of Circadian Rhythm
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Response To Activity
Cry-Per Complex
Negative Regulation Of Glucocorticoid Secretion
Nuclear Receptor Binding
Response To Blue Light
Response To Light Stimulus
Transcription Corepressor Binding
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Photoreceptor Activity
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Signal Transduction
Response To Radiation
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Cytoplasm
Lactate Metabolic Process
Regulation Of Hormone Secretion
Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Non-canonical Wnt Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Microtubule Nucleation
Protein Phosphorylation
Response To Muscle Activity
Negative Regulation Of Signal Transduction
Positive Regulation Of Wnt Signaling Pathway
Lipid Storage
Regulation Of G Protein-coupled Receptor Signaling Pathway
Dopaminergic Neuron Differentiation
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Phosphorylation
Negative Regulation Of Lipid Transport
FAD Binding
Protein Serine/threonine Kinase Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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Tagcloud (Intersection)
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