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AXIN2
Gene Name
axin 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoplasmic Microtubule
Plasma Membrane
Cell Cortex
Postsynaptic Density
Microtubule Cytoskeleton
Cytoplasmic Membrane-bounded Vesicle
Beta-catenin Destruction Complex
Molecular Function
GTPase Activator Activity
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Armadillo Repeat Domain Binding
I-SMAD Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Intramembranous Ossification
Secondary Heart Field Specification
Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
Cell Proliferation
Negative Regulation Of Cell Proliferation
Dorsal/ventral Axis Specification
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Cell Death
Bone Mineralization
Regulation Of Mismatch Repair
Cellular Protein Localization
Negative Regulation Of Catenin Import Into Nucleus
Termination Of G-protein Coupled Receptor Signaling Pathway
Odontogenesis
Positive Regulation Of GTPase Activity
Maintenance Of DNA Repeat Elements
Negative Regulation Of Osteoblast Differentiation
MRNA Stabilization
Regulation Of Chondrocyte Development
Regulation Of Centromeric Sister Chromatid Cohesion
Cellular Response To Organic Cyclic Compound
Negative Regulation Of Canonical Wnt Signaling Pathway
Wnt Signaling Pathway Involved In Somitogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of AXIN
Signaling by Wnt
binding of TCF/LEF:CTNNB1 to target gene promoters
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions
7 interactors:
ANKRD6
APC
APC2
CSNK1E
CTNNB1
GSK3B
SMAD3
Entrez ID
8313
HPRD ID
04935
Ensembl ID
ENSG00000168646
Uniprot IDs
E7ES00
Q9Y2T1
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of Signaling
Wnt Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Cell Cycle Process
Regulation Of Cell Morphogenesis
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Protein Catabolic Process
Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Regulation Of Proteolysis
Positive Regulation Of Stem Cell Differentiation
Regulation Of Phosphorus Metabolic Process
Regulation Of Signaling
Positive Regulation Of Proteolysis
Regulation Of Protein Localization
Negative Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Chromosome Segregation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Metabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Organelle Organization
Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process
Canonical Wnt Signaling Pathway
Regulation Of Cellular Component Organization
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Organelle Organization
Regulation Of Mitotic Cell Cycle
Regulation Of Cellular Localization
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Epithelial Cell Differentiation
Positive Regulation Of Cell Development
Tagcloud
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apposition
bending
bf
bfr
bones
canonical
compromised
csa
determinant
epsilon
histomorphometric
hz
ko
littermate
loaded
loading
mar
mechanical
mineral
nfatc1
periosteal
periosteum
reductions
tibia
tnnt2
unloaded
wnt
wnt16
wt