AXIN2 and KCNK12

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		AXIN2	KCNK12
Name		axin 2	potassium two pore domain channel subfamily K member 12
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases	Phase 4 - resting membrane potential
Diseases		Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Refractive error ( 32231278 )	Vitiligo ( 19890347 )
Interacting Genes		56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	1 interacting genes: AXIN2
Entrez ID		8313	56660
HPRD ID		04935	09562
Ensembl ID		ENSG00000168646	ENSG00000184261
Uniprot IDs		B7ZKL5 E7ES00 Q9Y2T1	Q9HB15
PDB IDs		8HEO	Not available
GO Terms Enriched among Interactors		Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus	Intramembranous Ossification Dorsal/ventral Axis Specification Negative Regulation Of Osteoblast Proliferation Maintenance Of DNA Repeat Elements Beta-catenin Destruction Complex Regulation Of Mismatch Repair Osteoblast Proliferation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Centromeric Sister Chromatid Cohesion Heart Field Specification Regulation Of Chondrocyte Development Mitral Valve Morphogenesis Secondary Heart Field Specification Specification Of Animal Organ Identity I-SMAD Binding Regulation Of Sister Chromatid Cohesion Atrioventricular Valve Morphogenesis Cellular Response To Dexamethasone Stimulus Regulation Of Osteoblast Proliferation Aortic Valve Morphogenesis Negative Regulation Of Osteoblast Differentiation Somitogenesis Regulation Of Extracellular Matrix Organization Chondrocyte Differentiation Positive Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus MRNA Stabilization Bone Mineralization Segmentation Cellular Response To Corticosteroid Stimulus Regulation Of Chondrocyte Differentiation Response To Dexamethasone Positive Regulation Of Epithelial To Mesenchymal Transition Heart Valve Morphogenesis Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Steroid Hormone Stimulus RNA Stabilization Stem Cell Proliferation Regulation Of Cartilage Development Axis Specification Beta-catenin Binding Negative Regulation Of RNA Catabolic Process Canonical Wnt Signaling Pathway Odontogenesis Negative Regulation Of MRNA Metabolic Process Biomineral Tissue Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Proteasomal Protein Catabolic Process