CSNK1E and ANKRD6

Number of citations of the paper that reports this interaction (PMID 12183362)
51

Data Source:
HPRD (two hybrid, in vivo)

		CSNK1E	ANKRD6
Gene Name		casein kinase 1, epsilon	ankyrin repeat domain 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS			vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227	2 interactors: AXIN2 CSNK1E
Entrez ID		1454	22881
HPRD ID		02919	09798
Ensembl ID		ENSG00000213923	ENSG00000135299
Uniprot IDs		B0QY34 P49674 Q5U045	B7Z3D2 Q9Y2G4
PDB IDs		4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Mismatch Repair Regulation Of Wnt Signaling Pathway Maintenance Of DNA Repeat Elements Regulation Of Cell Morphogenesis Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Centromeric Sister Chromatid Cohesion Intramembranous Ossification Negative Regulation Of Catenin Import Into Nucleus Regulation Of Sister Chromatid Cohesion Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Heart Formation Specification Of Organ Identity Regulation Of Catenin Import Into Nucleus DNA Metabolic Process Dorsal/ventral Axis Specification Negative Regulation Of Signal Transduction MRNA Stabilization Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Signal Transduction Cellular Protein Localization Bone Mineralization Negative Regulation Of Osteoblast Differentiation Organ Formation Regulation Of MRNA Stability Positive Regulation Of Stem Cell Differentiation Regulation Of RNA Stability Regulation Of Epithelial To Mesenchymal Transition Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of DNA Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Biomineral Tissue Development Negative Regulation Of Ossification Circadian Regulation Of Gene Expression Protein Localization Regulation Of Chromosome Segregation
Tagcloud ?		accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	analogous asymmetrically canonical consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates wnt
Tagcloud (Difference) ?		accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a	analogous asymmetrically canonical consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates wnt
Tagcloud (Intersection) ?