CSNK1E and ANKRD6

Number of citations of the paper that reports this interaction (PubMedID 12183362)
54

Data Source:
HPRD (in vivo, two hybrid)

		CSNK1E	ANKRD6
Description		casein kinase 1 epsilon	ankyrin repeat domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway	Establishment Or Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Seliciclib Umbralisib
Diseases
GWAS		Keratoconus ( 31855235) Mastocytosis ( 32752121)	Bipolar disorder ( 25827505) Coronary artery disease ( 29212778 33020668) Knee osteoarthritis ( 28916551) Metabolite levels (Pyroglutamine) ( 23934736) vWF and FVIII levels ( 21810271) Waist-hip ratio ( 28552196)
Interacting Genes		61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618	3 interacting genes: AXIN2 CSNK1E RIPK4
Entrez ID		1454	22881
HPRD ID		02919	09798
Ensembl ID		ENSG00000213923	ENSG00000135299
Uniprot IDs		P49674 Q5U045	A0A384MEC3 A0AA34QVS0 B7Z3D2 Q9Y2G4
PDB IDs		4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Mismatch Repair Regulation Of Wnt Signaling Pathway Intramembranous Ossification Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Chondrocyte Development Protein Serine Kinase Activity Maintenance Of DNA Repeat Elements Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Protein Catabolic Process Mitral Valve Morphogenesis Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Osteoblast Proliferation Secondary Heart Field Specification Beta-catenin Destruction Complex Heart Field Specification Negative Regulation Of Osteoblast Proliferation Protein Kinase Activity Dorsal/ventral Axis Specification Positive Regulation Of Non-canonical Wnt Signaling Pathway I-SMAD Binding Specification Of Animal Organ Identity Positive Regulation Of Catabolic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Amyloid-beta Formation Atrioventricular Valve Morphogenesis Circadian Behavior Kinase Activity Rhythmic Behavior Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process DNA Metabolic Process Positive Regulation Of Amide Metabolic Process Cellular Response To Dexamethasone Stimulus Regulation Of Osteoblast Proliferation Aortic Valve Morphogenesis Positive Regulation Of Protein Metabolic Process
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