AXIN2 and ZNF189

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		AXIN2	ZNF189
Name		axin 2	zinc finger protein 189
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex	Nucleus
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases	Generic Transcription Pathway
Diseases		Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	15 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 RBM11 SMAD4 SRC STK11
Entrez ID		8313	7743
HPRD ID		04935	11930
Ensembl ID		ENSG00000168646	ENSG00000136870
Uniprot IDs		B7ZKL5 E7ES00 Q9Y2T1	A0A087X0K2 B7ZLK9 O75820
PDB IDs		8HEO	Not available
GO Terms Enriched among Interactors		Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus	Regulation Of Cell Development Gland Development Animal Organ Morphogenesis Protein Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process Axis Specification Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Animal Organ Development Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Odontogenesis Cell Surface Receptor Signaling Pathway Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Gene Expression Nucleotide Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Centromeric Sister Chromatid Cohesion Cell Differentiation Regulation Of Wnt Signaling Pathway Reproductive Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Protein Phosphorylation LRR Domain Binding ATP Binding Regulation Of Cellular Component Organization Negative Regulation Of Locomotion Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Negative Regulation Of Wnt Signaling Pathway Mesendoderm Development Phosphorylation Regulation Of Intracellular Signal Transduction Mitral Valve Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Developmental Process