AXIN2 and APC2

Number of citations of the paper that reports this interaction (PMID 10021369)
18

Data Source:
BioGRID (two hybrid)

		AXIN2	APC2
Gene Name		axin 2	adenomatosis polyposis coli 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoplasmic Microtubule Plasma Membrane Cell Cortex Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Beta-catenin Destruction Complex	Golgi Membrane Cytoplasm Golgi Apparatus Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Lamellipodium Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Armadillo Repeat Domain Binding I-SMAD Binding	Protein Binding Beta-catenin Binding Microtubule Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Proliferation Negative Regulation Of Cell Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Negative Regulation Of Catenin Import Into Nucleus Termination Of G-protein Coupled Receptor Signaling Pathway Odontogenesis Positive Regulation Of GTPase Activity Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Organic Cyclic Compound Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Wnt Signaling Pathway Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANKRD6 APC APC2 CSNK1E CTNNB1 GSK3B SMAD3	5 interactors: AXIN2 CTNNB1 MAPRE1 MAPRE3 UBC
Entrez ID		8313	10297
HPRD ID		04935	09802
Ensembl ID		ENSG00000168646	ENSG00000115266
Uniprot IDs		E7ES00 Q9Y2T1	O95996
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Process Regulation Of Cell Morphogenesis Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Phosphorylation Positive Regulation Of Protein Catabolic Process Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Proteolysis Positive Regulation Of Stem Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Proteolysis Regulation Of Protein Localization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Chromosome Segregation Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Mitotic Cell Cycle Regulation Of Cellular Localization Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Regulation Of Osteoblast Differentiation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Cell Development	Positive Regulation Of Microtubule Plus-end Binding Regulation Of Centromeric Sister Chromatid Cohesion Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Sister Chromatid Cohesion Positive Regulation Of Wnt Signaling Pathway Dorsal/ventral Axis Specification Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Organ Formation Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Stem Cell Differentiation Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Protein Binding Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation Positive Regulation Of Type I Interferon Production Regulation Of Cartilage Development Positive Regulation Of Cell Death Regulation Of Type I Interferon Production Regulation Of Chondrocyte Development Axis Specification Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Dorsal/ventral Pattern Formation Positive Regulation Of Binding Regulation Of Osteoblast Differentiation Cell Proliferation Positive Regulation Of Protein Phosphorylation Odontogenesis Mitotic Cell Cycle Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mismatch Repair Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus
Tagcloud ?		apposition bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt wnt16 wt	anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin
Tagcloud (Difference) ?		apposition bending bf bfr bones canonical compromised csa determinant epsilon histomorphometric hz ko littermate loaded loading mar mechanical mineral nfatc1 periosteal periosteum reductions tibia tnnt2 unloaded wnt wnt16 wt	anaphase attenuation believed binds correlates cyclosome degradation demonstrates dispensable downregulated downregulation e3 implications knock ligase mdm2 oncoprotein polyubiquitination promoting proteasomal proto regulator rnai scaffold senescence shows stabilization ubiquitin
Tagcloud (Intersection) ?