AXIN2 and APC2

Number of citations of the paper that reports this interaction (PubMedID 10021369)
0

Data Source:
BioGRID (two hybrid)

		AXIN2	APC2
Description		axin 2	APC regulator of Wnt signaling pathway 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Beta-catenin Destruction Complex Protein-containing Complex	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Actin Filament Microtubule Cytoskeleton Catenin Complex Midbody Beta-catenin Destruction Complex Leading Edge Membrane Lamellipodium Membrane Filamentous Actin Intercellular Bridge Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Molecular Adaptor Activity I-SMAD Binding	Protein Binding Beta-catenin Binding Microtubule Binding Gamma-catenin Binding
	Biological Process	Osteoblast Differentiation Somitogenesis Intramembranous Ossification Secondary Heart Field Specification Aortic Valve Morphogenesis Mitral Valve Morphogenesis Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Dorsal/ventral Axis Specification Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Odontogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Repeat Elements Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Cell Development Response To Steroid Hormone Canonical Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Dexamethasone Stimulus Stem Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Microtubule Cytoskeleton Organization Cell Fate Specification Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Nervous System Development Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Activation Of GTPase Activity
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases		Oligodontia-colorectal cancer syndrome Tooth agenesis; Hypodontia	Colorectal cancer
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Refractive error ( 32231278)	Lean body mass ( 28552196)
Interacting Genes		56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SIAH1 SMAD1 SMAD3 SMAD7 SNCA STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	9 interacting genes: AXIN2 CTNNB1 DSCAM FXR1 MAPRE1 MAPRE3 NLGN3 SMARCA2 YAP1
Entrez ID		8313	10297
HPRD ID		04935	09802
Ensembl ID		ENSG00000168646	ENSG00000115266
Uniprot IDs		B7ZKL5 E7ES00 Q9Y2T1	O95996
PDB IDs		8HEO
Enriched GO Terms of Interacting Partners?		Beta-catenin Destruction Complex Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Binding Regulation Of Wnt Signaling Pathway I-SMAD Binding Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Cell-cell Junction Organization Heteromeric SMAD Protein Complex Regulation Of Cartilage Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signalosome Centrosome Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Ureteric Bud Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleus Cell Junction Organization Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Mesonephric Epithelium Development Mesonephric Tubule Development Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nucleocytoplasmic Transport Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process SMAD Protein Signal Transduction Positive Regulation Of Catabolic Process Response To Growth Factor Regulation Of Long-term Neuronal Synaptic Plasticity Kidney Epithelium Development Catenin Complex Regulation Of Intracellular Protein Transport Regulation Of Osteoblast Differentiation Identical Protein Binding Protein Binding Positive Regulation Of Cartilage Development Regulation Of Protein Localization To Nucleus Protein Catabolic Process Positive Regulation Of Protein Localization To Centrosome SMAD Protein Complex Regulation Of Protein Export From Nucleus	Regulation Of Cell Development Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Nervous System Development Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Regulation Of Neurogenesis Mitotic Spindle Astral Microtubule End Positive Regulation Of Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Cell Differentiation Regulation Of Developmental Process Positive Regulation Of Neurogenesis Regulation Of Microtubule Polymerization Neuron To Neuron Synapse Beta-catenin Destruction Complex Regulation Of Nephron Tubule Epithelial Cell Differentiation Cell Projection Membrane Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Microtubule Polymerization Or Depolymerization Dorsal/ventral Axis Specification Negative Regulation Of Microtubule Polymerization Protein Localization To Microtubule Regulation Of Epithelial Cell Differentiation Involved In Kidney Development I-SMAD Binding Regulation Of Sister Chromatid Cohesion Developmental Growth Involved In Morphogenesis Microtubule Plus-end Binding Cell Development Regulation Of Osteoblast Differentiation Protein Serine/threonine Kinase Binding Cellular Component Assembly Microtubule Plus-end Glandular Epithelial Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Spindle Midzone Lung Epithelial Cell Differentiation Lung Cell Differentiation Germ Cell Development Positive Regulation Of Cellular Component Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Chromosome Organization Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Synapse Organization Positive Regulation Of Stem Cell Population Maintenance
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