CSNK1E and ENTR1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CSNK1E	ENTR1
Description		casein kinase 1 epsilon	endosome associated trafficking regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Growth Cone Neuronal Cell Body Ribonucleoprotein Complex	Cytoplasm Endosome Early Endosome Centrosome Cytoskeleton Midbody Retromer Complex Ciliary Basal Body Cell Projection Recycling Endosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Intracellular Protein Localization Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Circadian Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Circadian Behavior Negative Regulation Of Small GTPase Mediated Signal Transduction Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway	Protein Transport Cell Projection Organization Endocytic Recycling Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Cell Division Positive Regulation Of Protein Localization To Cilium
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A AURKA Activation by TPX2 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		Seliciclib Umbralisib
Diseases
GWAS		Keratoconus ( 31855235) Mastocytosis ( 32752121)
Interacting Genes		61 interacting genes: AKAP17A AKAP9 ANKRD6 APC APP ARHGEF1 AXIN1 AXIN2 BBS10 BHLHE41 BID BMAL1 CADM4 CCDC14 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HAUS7 HES1 KAT7 NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD17 RAD54B RBX1 RORA RORC SNCA SOCS3 TAFAZZIN TAOK1 TLE5 TNS2 TRIM2 TRIM3 WDCP YAP1 ZMYND8 ZNF227 ZNF618	12 interacting genes: AP1M1 APP AXIN1 CD99 CHD3 CSNK1E DDX6 GIT1 NOD2 SDCBP SMURF1 VIM
Entrez ID		1454	10807
HPRD ID		02919	15307
Ensembl ID		ENSG00000213923	ENSG00000165689
Uniprot IDs		P49674 Q5U045	Q96C92
PDB IDs		4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Circadian Rhythm Regulation Of Signal Transduction Rhythmic Process Photoperiodism Regulation Of Cell Communication Regulation Of Signaling Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Radiation Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Circadian Rhythm Regulation Of Canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process E-box Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Signal Transduction Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Intracellular Signal Transduction Transcription Corepressor Binding Proteasomal Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Beta-catenin Binding Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription	Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Positive Regulation Of Proteolysis Cellular Response To Muramyl Dipeptide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Metabolic Process Regulation Of Interleukin-1 Production Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Growth Cone Protein Serine/threonine Kinase Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Focal Adhesion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muramyl Dipeptide R-SMAD Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Cellular Localization Frizzled Binding Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cytosol Cellular Response To Molecule Of Bacterial Origin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Catabolic Process Cytoplasm Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Protein Domain Specific Binding Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Plasma Membrane Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding
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