KNG1 and CPN1

Number of citations of the paper that reports this interaction (PubMedID 14687935)
0

Data Source:
HPRD (in vitro)

		KNG1	CPN1
Description		kininogen 1	carboxypeptidase N subunit 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Proteolysis Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Protein Catabolic Process Response To Glucocorticoid
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc ORE-1001 Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Blood protein levels ( 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757) Mean reticulocyte volume ( 32888494)
Interacting Genes		29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	6 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1
Entrez ID		3827	1369
HPRD ID		01970	09120
Ensembl ID		ENSG00000113889	ENSG00000120054
Uniprot IDs		P01042	P15169
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX	2NSM
Enriched GO Terms of Interacting Partners?		Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome	Complement Activation, Lectin Pathway Complement Activation, GZMK Pathway Blood Microparticle Killing Of Cells Of Another Organism Complement Activation, Alternative Pathway Cell Killing Positive Regulation Of Vascular Endothelial Growth Factor Production Leukocyte Migration Complement Activation, Classical Pathway Humoral Immune Response Regulation Of Vascular Endothelial Growth Factor Production Chemokine Activity Endopeptidase Inhibitor Activity Endoplasmic Reticulum Lumen Complement Activation Immune System Process Signaling Receptor Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding Extracellular Exosome Immune Effector Process Virus Coreceptor Activity Extracellular Region Immune Response Positive Regulation Of Activation Of Membrane Attack Complex GBD Domain Binding Storage Vacuole Hormone Activity Inflammatory Response Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Receptor Ligand Activity Vertebrate Eye-specific Patterning Endothelin Receptor Signaling Pathway Involved In Heart Process Glycosylated Region Protein Binding Leukocyte Chemotaxis Oviduct Epithelium Development Positive Regulation Of Type IIa Hypersensitivity Complement-mediated Synapse Pruning Extracellular Space Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Immature T Cell Proliferation In Thymus Immature T Cell Proliferation In Thymus Cell Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Complement Activation Positive Regulation Of Hypersensitivity Tissue Development G Protein-coupled Receptor Signaling Pathway
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