KNG1 and KLK1

Number of citations of the paper that reports this interaction (PubMedID 3643793)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KNG1	KLK1
Description		kininogen 1	kallikrein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Space Nucleus Secretory Granule Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Developmental Lineage of Pancreatic Acinar Cells
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate
Diseases
GWAS		Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1
Entrez ID		3827	3816
HPRD ID		01970	01003
Ensembl ID		ENSG00000113889	ENSG00000167748
Uniprot IDs		P01042	A0A1R3UCD2 P06870
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX	1SPJ 8YGY
Enriched GO Terms of Interacting Partners?		Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome	Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Extracellular Space Extracellular Matrix Extracellular Region Protease Binding Coagulation Blood Coagulation Hemostasis Blood Microparticle Extracellular Exosome Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Platelet Dense Granule Lumen Regulation Of Wound Healing Heparin Binding Regulation Of Response To Wounding Acute-phase Response Endopeptidase Inhibitor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Acute Inflammatory Response Negative Regulation Of Wound Healing Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Negative Regulation Of Complement Activation, Lectin Pathway Seminal Clot Liquefaction Interleukin-8 Binding Platelet Dense Tubular Network Inflammatory Response Acrosin Binding Positive Regulation Of Establishment Of Endothelial Barrier Tumor Necrosis Factor Binding Interleukin-1 Binding Negative Regulation Of Complement Activation Negative Regulation Of Defense Response Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Regulation Of Establishment Of Endothelial Barrier
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