KNG1 and THBS1

Number of citations of the paper that reports this interaction (PubMedID 9459346)
0

Data Source:
HPRD (in vivo)

		KNG1	THBS1
Description		kininogen 1	thrombospondin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity	Phosphatidylserine Binding Fibronectin Binding Protease Binding Endopeptidase Inhibitor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Angiogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Immune Response Response To Unfolded Protein Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Cortical volume ( 32963231) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (immediate recall) in normal cognition ( 29274321) Urate levels ( 31578528)
Interacting Genes		29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	52 interacting genes: APP BGN CALCR CALR CD36 CD47 CFH COL11A1 COL18A1 COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL7A1 CORO1A CTSG DCN DHFR DYRK1A ELANE F2 FBN2 FGA FGF2 FN1 HRG HSP90AA1 IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG PLSCR1 SCARB2 SPARC TFPI TGFB1 TGM2 TNFAIP6 TNFRSF11B WEE2-AS1 WWP2
Entrez ID		3827	7057
HPRD ID		01970	01765
Ensembl ID		ENSG00000113889	ENSG00000137801
Uniprot IDs		P01042	P07996
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE 7YYK
Enriched GO Terms of Interacting Partners?		Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome	Extracellular Matrix Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet-derived Growth Factor Binding Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Collagen Trimer Regulation Of Signal Transduction Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Endodermal Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Locomotion Fibrillar Collagen Trimer Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Heparin Binding Regulation Of Hemostasis Cell Surface Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Coagulation Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Wound Healing Animal Organ Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Coagulation Regulation Of Cell-substrate Adhesion Platelet Activation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Multicellular Organismal Process Hemostasis
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