KNG1 and ELANE

Number of citations of the paper that reports this interaction (PubMedID 12887060)
0

Data Source:
HPRD (in vitro)

		KNG1	ELANE
Description		kininogen 1	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Blood protein levels ( 30072576)
Interacting Genes		29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		3827	1991
HPRD ID		01970	00554
Ensembl ID		ENSG00000113889	ENSG00000197561
Uniprot IDs		P01042	P08246
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
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