KNG1 and F11

Number of citations of the paper that reports this interaction (PMID 1652157)
71

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KNG1	F11
Gene Name		kininogen 1	coagulation factor XI
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity
	Biological Process	Platelet Degranulation Smooth Muscle Contraction Inflammatory Response Negative Regulation Of Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Platelet Activation Negative Regulation Of Blood Coagulation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Plasminogen Activation Positive Regulation Of Fibrinolysis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) G alpha (q) signalling events GPCR downstream signaling Intrinsic Pathway Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs			Coagulation Factor IX 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Adiponectin levels ( 20876611)	Activated partial thromboplastin time ( 22703881) Response to statin therapy ( 20339536) Venous thromboembolism ( 21980494 23650146)
Protein-Protein Interactions		28 interactors: AGT APP CAPN1 CAPN2 CD93 CPN1 CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	7 interactors: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2
Entrez ID		3827	2160
HPRD ID		01970	07524
Ensembl ID			ENSG00000088926
Uniprot IDs		P01042	P03951
PDB IDs		2WOK 4ASQ 4ASR 4ECB 4ECC	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Fibrinolysis Regulation Of Fibrinolysis Protein Metabolic Process Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Response To Stress Blood Coagulation, Intrinsic Pathway Positive Regulation Of Fibrinolysis Defense Response Wound Healing Response To Wounding Negative Regulation Of Fibrinolysis Immune System Process Protein Processing Positive Regulation Of Wound Healing Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cell Activation Regulation Of Inflammatory Response Collagen Catabolic Process Immune Response Protein Activation Cascade Collagen Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Platelet Activation Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Protein Processing Positive Regulation Of Immune Response Positive Regulation Of Blood Coagulation Toll-like Receptor Signaling Pathway Peptide Hormone Processing Regulation Of Immune System Process Bradykinin Catabolic Process Positive Regulation Of Coagulation Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Metabolic Process	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Blood Coagulation, Intrinsic Pathway Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Cell Activation Negative Regulation Of Catalytic Activity Platelet Degranulation Response To Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Exocytosis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Inflammatory Response Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning
Tagcloud (Difference) ?		ace ace2 agt agtr1 agtr2 allele arrhythmias bdkrb2 converting correction county descent european gender genotyped haplotype haplotypes king ren replicated rs1492099 rs710448 sca snp snps sudden variation variations washington	adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning
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