KNG1 and F11

Number of citations of the paper that reports this interaction (PubMedID 291905)
17

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		KNG1	F11
Description		kininogen 1	coagulation factor XI
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Hormone Activity Protein Binding Heparin Binding Zinc Ion Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Serine-type Aminopeptidase Activity
	Biological Process	Inflammatory Response Negative Regulation Of Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Killing Of Cells Of Another Organism Vasodilation Positive Regulation Of Apoptotic Process Negative Regulation Of Proteolysis Negative Regulation Of Multicellular Organismal Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance	Proteolysis Blood Coagulation Hemostasis Regulation Of Blood Coagulation Plasminogen Activation Positive Regulation Of Fibrinolysis
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Post-translational protein phosphorylation	Intrinsic Pathway of Fibrin Clot Formation Defective F9 activation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Coagulation Factor IX (Recombinant) Human C1-esterase inhibitor 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonate (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinate (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidine 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidine N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidine Conestat alfa Thrombin Human thrombin Coagulation Factor IX Human Zinc chloride Zinc sulfate, unspecified form
Diseases			Factor XI deficiency; Plasma thromboplastin antecedent deficiency; Rosenthal syndrome
GWAS		Activated partial thromboplastin time ( 20303064 22703881 29403010) Adiponectin levels ( 20876611) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Factor XI ( 28053049) Glomerular filtration rate ( 29403010) Neuropathic pain in head and neck cancer ( 29884837) Plasma renin activity levels ( 25477429) Small vessel stroke ( 29123153) Thrombosis ( 26908601)	Activated partial thromboplastin time ( 22703881 29403010) Cardiac troponin-I levels ( 31014085) Factor XI ( 28053049) L-arginine levels ( 27656708) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)
Interacting Genes		29 interacting genes: AGT APP CAPN1 CAPN2 CD93 CPN1 CRYAA CTSG CTSK CTSL CTSS ECE1 ELANE F11 F2 FTL GP1BA HABP2 ITGB2 KLK1 KLKB1 KRT1 MEP1A PLAUR PLG PREP RXFP4 THBS1 VTN	7 interacting genes: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2
Entrez ID		3827	2160
HPRD ID		01970	07524
Ensembl ID		ENSG00000113889	ENSG00000088926
Uniprot IDs		P01042	D6RB32 P03951
PDB IDs		1NY2 2WOK 4ASQ 4ASR 4ECB 4ECC 5I25 6F27 6F3V 6F3W 6F3X 6F3Y 7EIB 7F2O 7F6H 7F6I 7QOT 7QOX 8VJX	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4CR5 4CR9 4CRA 4CRB 4CRC 4CRD 4CRE 4CRF 4CRG 4D76 4D7F 4D7G 4NA7 4NA8 4TY6 4TY7 4WXI 4X6M 4X6N 4X6O 4X6P 4Y8X 4Y8Y 4Y8Z 5E2O 5E2P 5EOD 5EOK 5EXL 5EXM 5EXN 5I25 5Q0D 5Q0E 5Q0F 5Q0G 5Q0H 5QCK 5QCL 5QCM 5QCN 5QQO 5QQP 5QTT 5QTV 5QTW 5QTY 5TKS 5TKT 5TKU 5WB6 6AOD 6C0S 6HHC 6I58 6R8X 6TS4 6TS5 6TS6 6TS7 6TWB 6USY 6VLU 6VLV 6W50 7CJ1 7MBO 7QOT 7V0Z 7V10 7V11 7V12 7V13 7V14 7V15 7V16 7V17 7V18 8BO3 8BO4 8BO5 8BO6 8BO7
Enriched GO Terms of Interacting Partners?		Peptidase Activity Protein Maturation Protein Processing Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Regulation Of Blood Coagulation Regulation Of Hemostasis Proteolysis Serine-type Peptidase Activity Extracellular Space Regulation Of Wound Healing Extracellular Exosome Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Extracellular Region Negative Regulation Of Coagulation Protein Metabolic Process Regulation Of Response To Wounding Negative Regulation Of Wound Healing Hydrolase Activity Regulation Of Biological Quality Fibrinolysis External Side Of Plasma Membrane Regulation Of Body Fluid Levels Negative Regulation Of Fibrinolysis Proteoglycan Binding Peptide Hormone Processing Heparin Binding Signaling Receptor Ligand Precursor Processing Extracellular Matrix Disassembly Positive Regulation Of Fibrinolysis Blood Coagulation Extracellular Matrix Coagulation Hemostasis Endolysosome Lumen Regulation Of Multicellular Organismal Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Blood Coagulation Macromolecule Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Multicellular Organismal Process Fibronectin Binding Positive Regulation Of Coagulation Biological Process Involved In Interaction With Symbiont Zymogen Activation Hormone Metabolic Process Neutrophil-mediated Killing Of Bacterium Lysosome	Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Fibrinolysis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Regulation Of Wound Healing Extracellular Matrix Regulation Of Response To Wounding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Extracellular Space Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Blood Microparticle Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Heparin Binding Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Extracellular Region Positive Regulation Of Coagulation Regulation Of Collagen Biosynthetic Process Acute-phase Response Regulation Of Collagen Metabolic Process Regulation Of Platelet Activation Positive Regulation Of Wound Healing Platelet Activation External Side Of Plasma Membrane Acute Inflammatory Response Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Proteolysis Signaling Receptor Binding Endopeptidase Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?