RABGEF1 and DCTN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RABGEF1	DCTN2
Description		RAB guanine nucleotide exchange factor 1	dynactin subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Kinetochore Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Microtubule-based Process Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Melanosome Transport Protein Localization To Centrosome
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	39 interacting genes: ABI2 BICD1 BICD2 BLOC1S1 BLOC1S2 BLOC1S6 CALM1 CCDC172 CENPH CEP44 COG3 DISC1 EGFR FXR1 FXR2 GADD45A GADD45G GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 OGT PAFAH1B1 RABGEF1 RINT1 RPGR SHANK3 SMARCD1 TSC1 TXLNB USHBP1 ZW10
Entrez ID		27342	10540
HPRD ID		11477	09568
Ensembl ID		ENSG00000154710	ENSG00000175203
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Microtubule-based Process Organelle Organization Organelle Assembly Transport Along Microtubule Centrosome Cytoskeleton-dependent Intracellular Transport Cytoplasm Microtubule-based Transport Dynactin Binding Organelle Transport Along Microtubule Organelle Localization Cellular Localization Establishment Of Organelle Localization Regulation Of Dendritic Spine Development Membraneless Organelle Assembly Microtubule-based Movement Regulation Of Cytoskeleton Organization Microtubule Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization To Organelle Intracellular Transport Axo-dendritic Transport Cytosol Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Dendritic Spine Development Cytoskeleton Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Microtubule Intracellular Protein Localization Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum BLOC-1 Complex Regulation Of Multicellular Organismal Process Anterograde Synaptic Vesicle Transport Regulation Of Organelle Organization Vesicle Cytoskeletal Trafficking Cytoskeleton Organization Positive Regulation Of Neurogenesis Axon Cytoplasm Modulation Of Chemical Synaptic Transmission Dynein Complex Binding Axonal Transport Central Region Of Growth Cone Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Dsl1/NZR Complex Intracellular Signaling Cassette Cytoskeletal Anchor Activity Regulation Of Postsynapse Organization Regulation Of Microtubule-based Process
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