RABGEF1 and RAB33B

Number of citations of the paper that reports this interaction (PubMedID 11718716)
0

Data Source:
HPRD (in vitro)

		RABGEF1	RAB33B
Description		RAB guanine nucleotide exchange factor 1	RAB33B, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Golgi Membrane Endosome Golgi Apparatus Golgi Lumen Membrane Phagophore Assembly Site Membrane Presynapse
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Autophagosome Assembly Regulation Of Cell Growth Intra-Golgi Vesicle-mediated Transport Autophagy Protein Transport Regulation Of Exocytosis Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Protein Localization To Phagophore Assembly Site Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Golgi Organization Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	Intra-Golgi traffic TBC/RABGAPs RAB geranylgeranylation
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	11 interacting genes: ACVR1 ATG16L1 ATG16L2 CCDC136 GOLGA2 RABEP1 RABGEF1 RUFY2 SIAH1 TGFBR1 USP6
Entrez ID		27342	83452
HPRD ID		11477	05808
Ensembl ID		ENSG00000154710	ENSG00000172007
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	A0A494C0Z5 Q9H082
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	6Y09 6ZAY
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Endosome Viral RNA Genome Replication Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Endocytosis Regulation Of Receptor-mediated Endocytosis Pharyngeal System Development Viral Genome Replication Transforming Growth Factor Beta Binding Recycling Endosome Phagophore Assembly Site Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Regulation Of Vesicle-mediated Transport Positive Regulation Of SMAD Protein Signal Transduction Protein Transport Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Vacuole-isolation Membrane Contact Site Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Organelle Assembly Reproductive Process Regulation Of SMAD Protein Signal Transduction Endocytic Vesicle Cardiac Septum Morphogenesis Early Endosome Regulation Of Receptor Internalization Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Axo-dendritic Transport Autophagosome C-terminal Protein Lipidation Regulation Of Apoptotic Signaling Pathway Developmental Process Involved In Reproduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis
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