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RABGEF1 and RNF11
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
RABGEF1
RNF11
Description
RAB guanine nucleotide exchange factor 1
ring finger protein 11
Image
No pdb structure
GO Annotations
Cellular Component
Nucleolus
Cytoplasm
Endosome
Early Endosome
Cytosol
Endocytic Vesicle
Dendrite
Early Endosome Membrane
Vesicle
Recycling Endosome
Presynaptic Endosome
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Endosome
Early Endosome
Recycling Endosome
Extracellular Exosome
Molecular Function
DNA Binding
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Zinc Ion Binding
Small GTPase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
DNA Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Leukocyte Migration
Protein Targeting To Membrane
Endocytosis
Receptor-mediated Endocytosis
Ras Protein Signal Transduction
Protein Transport
Vesicle-mediated Transport
Endosomal Transport
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Mast Cell Cytokine Production
Negative Regulation Of Mast Cell Activation
Kit Signaling Pathway
Mast Cell Degranulation
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Receptor-mediated Endocytosis
Negative Regulation Of Inflammatory Response
Establishment Of Localization In Cell
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Mast Cell Migration
Dendritic Transport
Negative Regulation Of Kit Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Pathways
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS
Aortic root size (
21223598
)
Central corneal thickness (
29760442
32528159
)
Atrial fibrillation (
29290336
)
Male-pattern baldness (
28196072
)
QRS duration (
21076409
)
Interacting Genes
49 interacting genes:
ABI2
ANKRD29
AP1G1
ARRDC3
BLOC1S6
CCHCR1
CDC37
CIPC
DAZAP2
DCTN2
DGCR6
DNAJC5
EMILIN1
GGA1
GGA2
GPRASP2
HOOK2
HRAS
IHO1
KXD1
MID2
MON1A
MON1B
OIP5
RAB33B
RAB4A
RABEP1
RAD23A
RASAL3
RNF11
RNF168
RPS27A
SESTD1
SNAPIN
SPART
SSX3
TCHP
TEAD4
THOC1
TRIM15
TRIM54
TXN2
UBA52
UBB
UBE2D1
UBE2D3
WASHC1
YWHAB
ZC2HC1C
69 interacting genes:
AKT1
ANKRD13A
ANKRD28
APP
ASCC2
AUP1
CALCOCO2
CBLB
CCDC127
DCUN1D1
EPN1
EPN2
EPN3
EPS15
ERCC6
FANCL
GGA1
GGA2
GGA3
HERC1
HERC2
HUWE1
IKBKG
ITCH
MYO6
NEDD4
NEDD4L
OPTN
PDCD6IP
POLI
PTPRC
QARS1
RABGEF1
RIPK1
RNF168
RNF216
RPS27A
SDCBP
SMURF1
SMURF2
SNRNP70
SPRTN
STAM2
STAMBP
TAX1BP1
TNFAIP3
TNIP1
TOM1L2
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBQLN2
UBQLN4
USP5
WWP1
WWP2
YAP1
ZFYVE16
ZFYVE9
ZNF350
Entrez ID
27342
26994
HPRD ID
11477
09955
Ensembl ID
ENSG00000154710
ENSG00000123091
Uniprot IDs
A8K3R3
B3KMF1
Q9UJ41
Q9Y3C5
PDB IDs
1TXU
2C7M
2C7N
2OT3
4N3X
4N3Y
4N3Z
4Q9U
Enriched GO Terms of Interacting Partners
?
Establishment Of Protein Localization
Protein Transport
Vesicle-mediated Transport
Intracellular Protein Localization
Protein Binding
Adipose Tissue Development
Protein Tag Activity
BLOC-1 Complex
Establishment Of Localization In Cell
Intracellular Transport
Ubiquitin Protein Ligase Binding
Recycling Endosome
Connective Tissue Development
Endosome
Protein Ubiquitination
Cellular Localization
Ubiquitin Protein Ligase Activity
Mon1-Ccz1 Complex
Vacuolar Transport
Organelle Transport Along Microtubule
Protein Modification By Small Protein Conjugation
Cytoplasm
Vesicle-mediated Transport In Synapse
Melanosome Organization
Vesicle
Endosome Membrane
Post-Golgi Vesicle-mediated Transport
Pigment Granule Organization
Modification-dependent Protein Catabolic Process
Ubiquitin Binding
Protein Localization To Ciliary Membrane
Regulation Of Lysosome Size
BORC Complex
Cytoskeleton-dependent Intracellular Transport
Early Endosome Membrane
Microvesicle
Protein Targeting
Early Endosome
Endosome To Melanosome Transport
Fat Pad Development
Regulation Of Endosome Size
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Cytosol
Post-translational Protein Modification
Vesicle-mediated Transport To The Plasma Membrane
Cytoplasmic Side Of Lysosomal Membrane
Proteolysis Involved In Protein Catabolic Process
Golgi To Plasma Membrane Transport
Intracellular Protein Transport
Secretion By Cell
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Modification Process
Macromolecule Catabolic Process
Protein Polyubiquitination
Proteolysis
Ubiquitin Binding
Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Ubiquitin Protein Ligase Activity
Cytosol
Macromolecule Metabolic Process
Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Monoubiquitination
Endosome
Ubiquitin Ligase Complex
Proteasomal Protein Catabolic Process
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Negative Regulation Of Signal Transduction
Positive Regulation Of Catabolic Process
Protein K63-linked Ubiquitination
Positive Regulation Of Protein Catabolic Process
K63-linked Polyubiquitin Modification-dependent Protein Binding
Transferase Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Post-translational Protein Modification
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Early Endosome Membrane
Positive Regulation Of Protein Modification Process
Autophagosome
Protein-containing Complex
Positive Regulation Of Post-translational Protein Modification
DNA Damage Response
Regulation Of Protein Ubiquitination
Cytoplasm
Cellular Response To Stress
Extracellular Exosome
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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