RABGEF1 and HOOK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RABGEF1	HOOK2
Description		RAB guanine nucleotide exchange factor 1	hook microtubule tethering protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Cytoskeleton Microtubule HOPS Complex FHF Complex
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Platelet distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	127 interacting genes: ABLIM1 AIRIM AKTIP ANKRD11 ANKRD36BP1 AP1M1 AP2M1 AP4M1 APEX2 ATG5 BYSL CABP2 CBX8 CCDC187 CCDC198 CCDC33 CCHCR1 CDK18 CDKN1A CEP95 CWF19L2 CYTH4 DCX DDX6 DUSP13B EIF3D ENKD1 EPS8 FAM107A FAM110A FAM161A FAM161B FAM50B FAM90A1 FGF16 FHIP1B FLYWCH1 GAS2L2 GEM GPKOW HAUS1 HDAC4 HOOK1 HOOK3 HOXB5 IL16 IPP IQCE ITSN2 KANSL1 KAT7 KIAA0408 KIF9 KLK15 KRT1 LENG1 LNX1 LRGUK MCM10 MCRS1 MFAP1 MORN3 MPPED2 MYLIP NEK6 OAS1 PARP11 PIMREG PKP1 PKP2 PPP1R18 PPP1R26 PRPF18 PRPF31 PRR35 PSMA1 PSMF1 RABGEF1 RALBP1 RBM41 RCOR3 RGS8 RIBC2 RITA1 RNF169 RNF6 SCNM1 SH2D4A SMARCB1 SNW1 SPATC1L SUV39H1 SYT17 SYT6 TBC1D22B TBC1D30 TCEA2 TCEANC TCHP TPM3 TSC1 TSGA10 TSGA10IP TTC23 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZFP1 ZFYVE26 ZGPAT ZNF107 ZNF250 ZNF35 ZNF417 ZNF48 ZNF497 ZNF572 ZNF587 ZNF638 ZNF648 ZNF835 ZNF844
Entrez ID		27342	29911
HPRD ID		11477	09698
Ensembl ID		ENSG00000154710	ENSG00000095066
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	Q96ED9
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Protein Binding FHF Complex HOPS Complex Protein Localization To Perinuclear Region Of Cytoplasm Centrosome Zinc Ion Binding Cytoskeleton Endosome To Lysosome Transport Spindle Pole Early Endosome To Late Endosome Transport Nucleus Lysosomal Transport Vacuole Organization Clathrin Adaptor Complex Lysosome Organization Microtubule Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Vacuolar Transport RNA Splicing
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