RABGEF1 and ARRDC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RABGEF1	ARRDC3
Description		RAB guanine nucleotide exchange factor 1	arrestin domain containing 3
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GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Cytoplasm Lysosome Endosome Early Endosome Plasma Membrane Membrane
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Beta-3 Adrenergic Receptor Binding
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Temperature Homeostasis Protein Transport Heat Generation Negative Regulation Of Heat Generation Positive Regulation Of Hippo Signaling Skin Development Positive Regulation Of Ubiquitin-protein Transferase Activity Fat Pad Development Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Cold-induced Thermogenesis
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)	Breast cancer ( 25038754 29059683) Breast cancer (prognosis) ( 23319801) Breast cancer (survival) ( 25526632) Platelet distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	36 interacting genes: ADRB2 BAG3 BCL6 CCDC50 CDA DCUN1D1 EFEMP2 EPN2 FAM90A1 HPGDS ITCH MAGI2 MORF4L1 OPTN OTUB2 PDCD6IP PHF1 PRKAA2 RABGEF1 RACK1 RAD18 SMARCD1 STAM2 TNFAIP3 TOLLIP TRIM42 UBA52 UBAC1 UBASH3A UBE2D1 UBE2D2 UBE2E2 UBE2E3 UBQLN2 WWP2 ZRANB1
Entrez ID		27342	57561
HPRD ID		11477	09810
Ensembl ID		ENSG00000154710	ENSG00000113369
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	Q96B67
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U	4N7H 4R7V 4R7X
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Polyubiquitin Modification-dependent Protein Binding Protein Modification Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Autophagy Negative Regulation Of Signal Transduction Cytosol Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Monoubiquitination Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Protein Autoubiquitination Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Endosome Negative Regulation Of Intracellular Signal Transduction Protein K63-linked Deubiquitination K63-linked Polyubiquitin Modification-dependent Protein Binding Proteolysis Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Gene Expression Nucleoplasm Regulation Of Germinal Center Formation Cytoplasm Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein Binding Positive Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Nucleus Regulation Of Protein Modification Process Catabolic Process Negative Regulation Of Endocytosis Positive Regulation Of Autophagy Receptor-mediated Endocytosis Regulation Of Signal Transduction Tolerance Induction Cellular Response To Unfolded Protein
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