RABGEF1 and MON1A

Number of citations of the paper that reports this interaction (PubMedID 20434987)
0

Data Source:
BioGRID (pull down)

		RABGEF1	MON1A
Description		RAB guanine nucleotide exchange factor 1	MON1 vesicular trafficking associated A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Dendrite Early Endosome Membrane Vesicle Recycling Endosome Presynaptic Endosome	Cytosol Mon1-Ccz1 Complex
	Molecular Function	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Receptor-mediated Endocytosis Ras Protein Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Negative Regulation Of Interleukin-6 Production Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Activation Kit Signaling Pathway Mast Cell Degranulation Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Establishment Of Localization In Cell Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mast Cell Migration Dendritic Transport Negative Regulation Of Kit Signaling Pathway	Protein Targeting To Vacuole Protein Secretion Vesicle-mediated Transport
Pathways		TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aortic root size ( 21223598) Central corneal thickness ( 29760442 32528159)	Age at first birth ( 27798627) Body mass index ( 28892062 29273807 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		49 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C	6 interacting genes: GFI1B MAPK6 RABGEF1 RGS2 TAB1 VPS33A
Entrez ID		27342	84315
HPRD ID		11477	17586
Ensembl ID		ENSG00000154710	ENSG00000164077
Uniprot IDs		A8K3R3 B3KMF1 Q9UJ41	Q86VX9
PDB IDs		1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Protein Transport Vesicle-mediated Transport Intracellular Protein Localization Protein Binding Adipose Tissue Development Protein Tag Activity BLOC-1 Complex Establishment Of Localization In Cell Intracellular Transport Ubiquitin Protein Ligase Binding Recycling Endosome Connective Tissue Development Endosome Protein Ubiquitination Cellular Localization Ubiquitin Protein Ligase Activity Mon1-Ccz1 Complex Vacuolar Transport Organelle Transport Along Microtubule Protein Modification By Small Protein Conjugation Cytoplasm Vesicle-mediated Transport In Synapse Melanosome Organization Vesicle Endosome Membrane Post-Golgi Vesicle-mediated Transport Pigment Granule Organization Modification-dependent Protein Catabolic Process Ubiquitin Binding Protein Localization To Ciliary Membrane Regulation Of Lysosome Size BORC Complex Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Microvesicle Protein Targeting Early Endosome Endosome To Melanosome Transport Fat Pad Development Regulation Of Endosome Size Negative Regulation Of Cellular Response To Growth Factor Stimulus Cytosol Post-translational Protein Modification Vesicle-mediated Transport To The Plasma Membrane Cytoplasmic Side Of Lysosomal Membrane Proteolysis Involved In Protein Catabolic Process Golgi To Plasma Membrane Transport Intracellular Protein Transport Secretion By Cell	Septin Cytoskeleton Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Intracellular Transport Organelle Localization Lysosome Localization Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Autophagosome Vesicle Localization Kit Signaling Pathway Adenylate Cyclase Inhibitor Activity Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Relaxation Of Smooth Muscle Relaxation Of Vascular Associated Smooth Muscle Mitogen-activated Protein Kinase P38 Binding Cellular Localization Establishment Of Localization In Cell Endosome Transport Along Microtubule Mast Cell Migration Negative Regulation Of Mast Cell Degranulation Cytoskeleton-dependent Intracellular Transport CORVET Complex Late Endosome Plus-end-directed Vesicle Transport Along Microtubule Plus-end-directed Organelle Transport Along Microtubule Positive Regulation Of Autophagosome Maturation Positive Regulation Of CGAS/STING Signaling Pathway Microtubule-based Transport Presynaptic Endosome Clathrin Complex Intracellular Signaling Cassette Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Mast Cell Activation
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