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RABGEF1
Gene Name
RAB guanine nucleotide exchange factor (GEF) 1
Image
Gene Ontology Annotations
Cellular Component
Early Endosome
Vesicle
Recycling Endosome
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Rab Guanyl-nucleotide Exchange Factor Activity
Rab GTPase Binding
Biological Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Leukocyte Migration
Protein Targeting To Membrane
Endocytosis
Protein Ubiquitination
Positive Regulation Of Rab GTPase Activity
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Receptor-mediated Endocytosis
Negative Regulation Of Inflammatory Response
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Negative Regulation Of Interleukin-6 Secretion
Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Aortic root size (
21223598
)
Protein-protein Interactions
30 interactors:
AP1G1
BLOC1S6
CIPC
DAZAP2
DGCR6
GGA1
GGA2
HRAS
KXD1
L1CAM
MON1A
MON1B
RAB21
RAB33B
RAB4A
RABEP1
RNF11
RNF168
RPS27A
TEAD4
THOC1
TRIM15
TRIM54
TXN2
UBB
UBC
UBE2D1
UBE2D3
YWHAB
ZC2HC1C
Entrez ID
27342
HPRD ID
11477
Ensembl ID
ENSG00000243335
Uniprot IDs
B4DZM7
Q9UJ41
PDB IDs
1TXU
2C7M
2C7N
2OT3
Enriched GO Terms of Interacting Partners
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Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Regulation Of Immune System Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Immune Response
Intracellular Transport Of Virus
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Protein Polyubiquitination
Intracellular Transport
Positive Regulation Of Innate Immune Response
Establishment Of Localization In Cell
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Regulation Of Type I Interferon Production
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Protein Transport
Innate Immune Response
DNA-templated Transcription, Initiation
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Type I Interferon Production
Viral Protein Processing
Response To Growth Factor
Establishment Of Protein Localization
Regulation Of Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Immune System Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Activation Of Innate Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Immune Response-regulating Signaling Pathway
Cellular Localization
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Immune Response
Mitotic Cell Cycle Checkpoint
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud
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abca7
adssl1
apoe
bin1
cd2ap
cd33
cognitively
cr1
epha1
fbxl2
hallmark
haplotype
intron
load
map2k4
modifier
ms4a4a
ms4a6e
multifactorial
picalm
plink
pomt2
ppp2r5c
sh3kbp1
snp
snx8
synj1
xpo1
xrn1