PRKCSH and GBA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRKCSH	GBA3
Gene Name		protein kinase C substrate 80K-H	glucosidase, beta, acid 3 (gene/pseudogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cytosol
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Ion Channel Binding Phosphoprotein Binding	Beta-galactosidase Activity Beta-glucosidase Activity Glycosylceramidase Activity
	Biological Process	Protein Folding N-glycan Processing Protein N-linked Glycosylation Via Asparagine Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response	Carbohydrate Metabolic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Glycoside Catabolic Process Small Molecule Metabolic Process Glycosylceramide Catabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Defective ALG11 causes ALG11-CDG (CDG-1p) Innate Immune System Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle	Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARL4D CANX GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR	1 interactors: PRKCSH
Entrez ID		5589	57733
HPRD ID		03518	09428
Ensembl ID		ENSG00000130175	ENSG00000249948
Uniprot IDs		K7ELL7 P14314	A8K9N1 B7Z536 Q9H227
PDB IDs			2E9L 2E9M 2JFE 2ZOX 3VKK
Enriched GO Terms of Interacting Partners?		T Cell Differentiation In Thymus T Cell Proliferation Protein N-linked Glycosylation Via Asparagine Vitamin D Receptor Signaling Pathway Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Lymphocyte Proliferation Mononuclear Cell Proliferation Protein N-linked Glycosylation Cellular Localization Leukocyte Proliferation Protein Secretion Positive Regulation Of Vitamin D 24-hydroxylase Activity Bile Acid Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Secretion Establishment Of Protein Localization T Cell Differentiation Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Activation-induced Cell Death Of T Cells Regulation Of Adrenergic Receptor Signaling Pathway Oogenesis Stage Negative Regulation Of T Cell Mediated Cytotoxicity Placenta Development Mammary Gland Branching Involved In Pregnancy Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Cardiac Muscle Contraction Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Glycoside Catabolic Process Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Post-translational Protein Modification Multicellular Organismal Reproductive Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Multicellular Organism Reproduction Protein Insertion Into ER Membrane Negative Regulation Of Kinase Activity Establishment Of Protein Localization To Membrane Chemical Homeostasis Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation T Cell Proliferation Involved In Immune Response Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Relaxation Of Vascular Smooth Muscle Regulation Of Isotype Switching To IgG Isotypes See more	N-glycan Processing
Tagcloud ?		abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3	abolishes abp abps azide aziridine cazy cyclophellitol epoxide exoglucosidases exploit femtomoles gba2 gh1 gh116 gh30 glucosidase glucosidases glycosidic glycosylhydrolase lph mutagenized nanograms noncarboxylic nucleophile operate protonated retaining thereof
Tagcloud (Difference) ?		abolished antisense axial coreceptors deglycosylation dickkopf1 dkk1 endoplasmic erlectin glycan glycoprotein head homology kremen1 krm1 krm2 mannose member morpholino mrh organogenesis proteomic resident reticulum reveals synexpression traffic xenopus xtp3	abolishes abp abps azide aziridine cazy cyclophellitol epoxide exoglucosidases exploit femtomoles gba2 gh1 gh116 gh30 glucosidase glucosidases glycosidic glycosylhydrolase lph mutagenized nanograms noncarboxylic nucleophile operate protonated retaining thereof
Tagcloud (Intersection) ?