PRKCSH

Name	PRKCSH beta subunit of glucosidase II
Structure
Novel Interactors	1 novel interactors: SMARCA4
Interactors	11 interactors: ARL4D CANX ESR1 FXR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Protein Binding Transmembrane Transporter Binding Metal Ion Binding Phosphoprotein Binding
	Biological Process	Liver Development N-glycan Processing Intracellular Signal Transduction
Pathways	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Diseases	Polycystic liver disease
GWAS	Presence of antiphospholipid antibodies ( 27098658 ) Serum metabolite levels (CMS) ( 31636271 )
Entrez ID	5589
HPRD ID	03518
Ensembl ID	ENSG00000130175
Uniprot IDs	B4DJQ5 K7ELL7 P14314
PDB IDs	8D43 8EMR
GO Terms Enriched among Interactors ?	Maternal Process Involved In Female Pregnancy Mammary Gland Branching Involved In Pregnancy Nucleolus Branching Involved In Mammary Gland Duct Morphogenesis Nuclear Steroid Receptor Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Membrane RNA Binding ERAD Pathway Presynapse Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Transcription Preinitiation Complex Assembly TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Transcription Coregulator Binding Regulation Of MiRNA Transcription Positive Regulation Of Catalytic Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of MiRNA Metabolic Process Developmental Process Involved In Reproduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Biosynthetic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity Antral Ovarian Follicle Growth Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Cell Differentiation DN2 Thymocyte Differentiation Plasma Membrane Raft Distribution Cytoplasmic Side Of Plasma Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Response To Alcohol Membrane Microdomain Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Glycine Import Across Plasma Membrane Adenylate Cyclase Inhibitor Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Cytoplasmic Ribonucleoprotein Granule