PRKCSH and RPS6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRKCSH	RPS6
Description		PRKCSH beta subunit of glucosidase II	ribosomal protein S6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Dendrite Small-subunit Processome Cytoplasmic Ribonucleoprotein Granule Cell Body Presynapse GABA-ergic Synapse Ribonucleoprotein Complex
	Molecular Function	Protein Kinase C Binding Calcium Ion Binding Protein Binding Transmembrane Transporter Binding Metal Ion Binding Phosphoprotein Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding
	Biological Process	Liver Development N-glycan Processing Intracellular Signal Transduction	Ribosomal Small Subunit Assembly Cytoplasmic Translation RRNA Processing Translation Positive Regulation Of Cell Population Proliferation TOR Signaling Response To Insulin Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Cellular Response To Ethanol Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Response of EIF2AK4 (GCN2) to amino acid deficiency Nuclear events stimulated by ALK signaling in cancer SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases		Polycystic liver disease
GWAS		Presence of antiphospholipid antibodies ( 27098658) Serum metabolite levels (CMS) ( 31636271)	Total cholesterol levels ( 29083408)
Interacting Genes		11 interacting genes: ARL4D CANX ESR1 FXR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR	20 interacting genes: ATF4 DUX4 EIF4ENIF1 ERCC6 FNDC3B FRS2 MTOR MYOM2 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH PTEN RPS6KB1 RPS6KB2 STAU1 UPF2 USP7
Entrez ID		5589	6194
HPRD ID		03518	01592
Ensembl ID		ENSG00000130175	ENSG00000137154
Uniprot IDs		B4DJQ5 K7ELL7 P14314	A2A3R6 P62753
PDB IDs		8D43 8EMR	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6F4P 6F4Q 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 7ZJW 7ZJX 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Maternal Process Involved In Female Pregnancy Mammary Gland Branching Involved In Pregnancy Nucleolus Branching Involved In Mammary Gland Duct Morphogenesis Nuclear Steroid Receptor Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Membrane RNA Binding ERAD Pathway Presynapse Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Transcription Preinitiation Complex Assembly TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Transcription Coregulator Binding Regulation Of MiRNA Transcription Positive Regulation Of Catalytic Activity Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of MiRNA Metabolic Process Developmental Process Involved In Reproduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Steroid Hormone Receptor Signaling Pathway Regulation Of Inflammatory Response Negative Regulation Of Biosynthetic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor Activity Antral Ovarian Follicle Growth Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Cell Differentiation DN2 Thymocyte Differentiation Plasma Membrane Raft Distribution Cytoplasmic Side Of Plasma Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Differentiation Response To Alcohol Membrane Microdomain Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Glycine Import Across Plasma Membrane Adenylate Cyclase Inhibitor Activity Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Cytoplasmic Ribonucleoprotein Granule	TORC1 Signaling TOR Signaling Cellular Response To Nutrient Levels Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Translational Initiation Cytoplasm Positive Regulation Of Transcription By RNA Polymerase I PML Body Negative Regulation Of TORC2 Signaling Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Protein Serine Kinase Activity Negative Regulation Of Cell Size Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair Cellular Response To Leucine Starvation Regulation Of Translation Regulation Of Cellular Response To Insulin Stimulus Regulation Of TORC2 Signaling Cytoplasmic Ribonucleoprotein Granule Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway TORC2 Signaling Vascular Endothelial Cell Response To Fluid Shear Stress Myelin Maintenance Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Signal Transduction Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Assembly Cellular Response To Laminar Fluid Shear Stress Cellular Response To Stress Autophagosome Organization Protein Kinase Activity Negative Regulation Of Autophagy Response To Laminar Fluid Shear Stress Positive Regulation Of Catabolic Process Cytoplasmic Translation
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