SEM1 and RPA1

Number of citations of the paper that reports this interaction (PubMedID 26145171)
64

Data Source:
BioGRID (pull down, x-ray crystallography)

		SEM1	RPA1
Description		SEM1 26S proteasome subunit	replication protein A1
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Lid Subcomplex Integrator Complex Protein-containing Complex	Nuclear Chromosome Chromosome, Telomeric Region Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm DNA Replication Factor A Complex PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Zinc Ion Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-rich Strand Telomeric DNA Binding Chromatin-protein Adaptor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development DNA Replication DNA-templated DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination Chromatin Organization DNA Damage Response Telomere Maintenance Via Telomerase Positive Regulation Of Cell Population Proliferation Hemopoiesis Protein Localization To Chromosome Homeostasis Of Number Of Cells Within A Tissue Chromosome Organization Meiotic Cell Cycle Protein Localization To Site Of Double-strand Break
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Impaired BRCA2 binding to SEM1 (DSS1) Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Airway imaging phenotypes ( 26030696) Bipolar disorder ( 31043756) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: BRCA2 MAP1LC3B NUDT21 PCID2 PSMD3 PSMD6 RAD51 RAD52 RPA1 USP14	70 interacting genes: AICDA AJUBA AKTIP ASCC2 ATM ATR BLM BRCA2 BRIP1 CCNA1 CEBPA CPE CSNK2B DMC1 EHMT2 ERCC1 ERCC4 GNB5 GRB2 HAX1 HELB HGH1 HIRA HNRNPUL1 HSPA6 HUS1 KAT2A KAT2B MCM2 MCM7 MMS22L MSH4 MTUS2 MUTYH ORC2 ORC6 PAXIP1 PCNA POLL PRIMPOL PRKDC PRPF19 RAD1 RAD23B RAD51 RAD52 RAD9A RBM23 RECQL RFWD3 RIPK1 RNF20 RNF40 RPA2 RPA3 RPA4 RPS6KA5 SELENBP1 SEM1 SMAD3 TCEA2 TK1 TP53 TREX1 VIM WAS WRN XPA XPC ZBTB14
Entrez ID		7979	6117
HPRD ID		03182	01565
Ensembl ID		ENSG00000127922	ENSG00000132383
Uniprot IDs		A0A087WYU0 A0A096LP17 A0A096LP28 F2Z2N6 F2Z309 P60896 Q6IBB7	P27694
PDB IDs		1IYJ 1MIU 1MJE 3T5X 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFR 5VFT 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8YJB 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	1EWI 1FGU 1JMC 1L1O 2B29 2B3G 4IJH 4IJL 4IPC 4IPD 4IPG 4IPH 4LUO 4LUV 4LUZ 4LW1 4LWC 4NB3 4O0A 4R4C 4R4I 4R4O 4R4Q 4R4T 5E7N 5EAY 5N85 5N8A 7XUT 7XUV 7XUW 7XV0 7XV1 7XV4 8JZV 8JZY 8K00 8RK2 9J1S 9MJ5
Enriched GO Terms of Interacting Partners?		Lateral Element Mitotic Recombination-dependent Replication Fork Processing Mitotic Recombination Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombinase Assembly Nuclear Ubiquitin Ligase Complex Proteasome Complex Double-strand Break Repair DNA Recombination Proteasome Regulatory Particle Regulation Of Lymphoid Progenitor Cell Differentiation Telomere Maintenance Telomere Maintenance Via Recombination Chromosome Organization Proteasome Accessory Complex Protein-containing Complex Telomere Organization Regulation Of DNA Damage Checkpoint Response To X-ray Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome DNA Repair Condensed Chromosome Regulation Of Cellular Response To Stress Replication Fork Processing Meiosis I Regulation Of Hematopoietic Progenitor Cell Differentiation Macromolecule Metabolic Process Condensed Nuclear Chromosome Male Germ Cell Nucleus Response To Gamma Radiation Nucleotide-excision Repair BRCA2-MAGE-D1 Complex Response To Glucoside Double-strand Break Repair Via Single-strand Annealing Positive Regulation Of Pro-B Cell Differentiation Nucleic Acid Metabolic Process DNA Metabolic Process Meiosis I Cell Cycle Process Cellular Response To Ionizing Radiation Meiotic Nuclear Division DNA Damage Response DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Nuclear Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Site Of Double-strand Break	DNA Metabolic Process DNA Repair DNA Damage Response DNA Recombination Cellular Response To Stress Double-strand Break Repair Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Nucleobase-containing Compound Metabolic Process Response To Stress Signal Transduction In Response To DNA Damage Macromolecule Metabolic Process Single-stranded DNA Binding Cellular Response To Radiation Nucleoplasm DNA Replication Nucleotide-excision Repair DNA Damage Checkpoint Signaling Response To Ionizing Radiation Response To Radiation Site Of Double-strand Break Replication Fork Processing Chromosome, Telomeric Region Chromosome Organization Cellular Response To Ionizing Radiation Telomere Maintenance Regulation Of DNA Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Telomere Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Mismatch Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Response To UV Regulation Of Cellular Response To Stress DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Damaged DNA Binding DNA Replication Factor A Complex MutLalpha Complex Binding Response To Gamma Radiation Mitotic Recombination DNA Helicase Activity
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