SEM1 and RAD52

Number of citations of the paper that reports this interaction (PubMedID 31799622)
75

Data Source:
BioGRID (pull down)

		SEM1	RAD52
Description		SEM1 26S proteasome subunit	RAD52 DNA repair protein
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Lid Subcomplex Integrator Complex Protein-containing Complex	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Protein Binding	DNA Binding Single-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination MRNA Export From Nucleus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Repair Double-strand Break Repair DNA Recombination Mitotic Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Oxidative Stress Double-strand Break Repair Via Single-strand Annealing Regulation Of Nucleotide-excision Repair
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 translocation to the nucleus Impaired BRCA2 binding to RAD51 KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Impaired BRCA2 binding to SEM1 (DSS1) Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ)
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)	Body mass index ( 26426971) Eosinophil percentage of granulocytes ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lung cancer ( 22899653) Neutrophil percentage of granulocytes ( 27863252) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: BRCA2 MAP1LC3B NUDT21 PCID2 PSMD3 PSMD6 RAD51 RAD52 RPA1 USP14	25 interacting genes: ABL1 AURKB DCP1A ERCC1 ERCC2 ERCC3 ERCC4 KPNA3 KPNA5 MCM2 MCM3 MEOX1 MEOX2 NFYC PAX5 PLK3 RAD51 RDM1 RPA1 RPA2 SEM1 SUMO1 TTK UBE2I WRN
Entrez ID		7979	5893
HPRD ID		03182	11855
Ensembl ID		ENSG00000127922	ENSG00000002016
Uniprot IDs		A0A087WYU0 A0A096LP17 A0A096LP28 F2Z2N6 F2Z309 P60896 Q6IBB7	B7Z2G8 B7Z5Q6 F5GX32 P43351 Q5DR82
PDB IDs		1IYJ 1MIU 1MJE 3T5X 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFR 5VFT 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8YJB 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	1H2I 1KN0 5JRB 5XRZ 5XS0 8BJM 8H1P 8RIL 8RJ3 8RJW 8TKQ
Enriched GO Terms of Interacting Partners?		Lateral Element Mitotic Recombination-dependent Replication Fork Processing Mitotic Recombination Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombinase Assembly Nuclear Ubiquitin Ligase Complex Proteasome Complex Double-strand Break Repair DNA Recombination Proteasome Regulatory Particle Regulation Of Lymphoid Progenitor Cell Differentiation Telomere Maintenance Telomere Maintenance Via Recombination Chromosome Organization Proteasome Accessory Complex Protein-containing Complex Telomere Organization Regulation Of DNA Damage Checkpoint Response To X-ray Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome DNA Repair Condensed Chromosome Regulation Of Cellular Response To Stress Replication Fork Processing Meiosis I Regulation Of Hematopoietic Progenitor Cell Differentiation Macromolecule Metabolic Process Condensed Nuclear Chromosome Male Germ Cell Nucleus Response To Gamma Radiation Nucleotide-excision Repair BRCA2-MAGE-D1 Complex Response To Glucoside Double-strand Break Repair Via Single-strand Annealing Positive Regulation Of Pro-B Cell Differentiation Nucleic Acid Metabolic Process DNA Metabolic Process Meiosis I Cell Cycle Process Cellular Response To Ionizing Radiation Meiotic Nuclear Division DNA Damage Response DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Nuclear Division Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Site Of Double-strand Break	DNA Repair DNA Damage Response DNA Metabolic Process Nucleus Double-strand Break Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Recombination Chromosome, Telomeric Region Nucleotide-excision Repair Single-stranded DNA Binding Damaged DNA Binding Regulation Of DNA Metabolic Process DNA Binding UV Protection Nucleoplasm Cellular Response To Stress Telomere Maintenance Protein Localization To Organelle PML Body Nucleic Acid Metabolic Process Chromosome Organization Telomere Organization Mismatch Repair Response To UV Response To Radiation DNA Helicase Activity Nucleobase-containing Compound Metabolic Process 3'-5' DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Maintenance Via Recombination Helicase Activity ATP Binding DNA Replication Repair Of Mitotic Kinetochore Microtubule Attachment Defect DNA Conformation Change Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Phase Transition Mitotic Recombination Cellular Response To Radiation Regulation Of Mitotic Cell Cycle Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Response To Light Stimulus Negative Regulation Of Protection From Non-homologous End Joining At Telomere Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Nucleotide Binding Response To Oxidative Stress
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