BIRC6 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 15300255)
0

Data Source:
HPRD (in vitro)

		BIRC6	CASP9
Description		baculoviral IAP repeat containing 6	caspase 9
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Midbody Flemming Body	Nucleus Cytoplasm Mitochondrion Cytosol Caspase Complex Protein-containing Complex Apoptosome
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Transferase Activity Peptidase Inhibitor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Placenta Development Protein Phosphorylation Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Hypoxia Kidney Development Response To Ischemia Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Protein Processing Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Neuron Apoptotic Process Protein Maturation Cellular Response To Dexamethasone Stimulus Response To Indole-3-methanol Leukocyte Apoptotic Process Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Epithelial Cell Apoptotic Process
Pathways		ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases
GWAS		Chronotype ( 30696823) Coffee consumption ( 31046077) General risk tolerance (MTAG) ( 30643258) Male-pattern baldness ( 28196072) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		29 interacting genes: ARIH1 BIRC2 BIRC5 CASP3 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 GABARAP HTRA2 MAP1LC3B MAP2K1 NEDD4 PLK1 RAB8A RACK1 RNF144A RNF4 RNF41 UBA6 UBC UBE2D1 UBE3C USP8 VAV2 VCL	47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		57448	842
HPRD ID		05731	03756
Ensembl ID		ENSG00000115760	ENSG00000132906
Uniprot IDs		A0A8V8TQB4 A0A8V8TR92 Q9NR09	F8VVS7 P55211
PDB IDs		3CEG 8ATM 8ATO 8ATU 8ATX 8AUK 8AUW 8E2D 8E2E 8E2F 8E2G 8E2H 8E2I 8E2K	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Proteolysis Cytosol Protein Modification By Small Protein Conjugation Protein Modification Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Catabolic Process Programmed Cell Death Cell Death Midbody Mitotic Cytokinesis Response To Anesthetic Execution Phase Of Apoptosis Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Polyubiquitination Cytoskeleton-dependent Cytokinesis Response To Cobalt Ion CD40 Receptor Complex Regulation Of Macroautophagy Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Protein Localization Cytoplasm Transferase Activity Regulation Of Protein Catabolic Process Golgi Inheritance Positive Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Cysteine-type Endopeptidase Activity DNA Damage Response Cellular Response To Stress Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Localization To Site Of Double-strand Break Macromolecule Metabolic Process	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Execution Phase Of Apoptosis Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Neuron Apoptotic Process Pyroptotic Inflammatory Response Bergmann Glial Cell Differentiation Regulation Of Golgi Inheritance Negative Regulation Of Apoptotic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Cysteine-type Endopeptidase Inhibitor Activity Glial Cell Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Modification Process Schwann Cell Development Regulation Of Neuron Apoptotic Process Trachea Formation Response To Lipid Regulation Of Innate Immune Response Regulation Of Metabolic Process Face Development Positive Regulation Of Biosynthetic Process Thymus Development
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