BIRC6 and ARIH1

Number of citations of the paper that reports this interaction (PubMedID 36758106)
0

Data Source:
BioGRID (enzymatic study)

		BIRC6	ARIH1
Description		baculoviral IAP repeat containing 6	ariadne RBR E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Midbody Flemming Body	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Transferase Activity Peptidase Inhibitor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Placenta Development Protein Phosphorylation Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PKR/eIFalpha Signaling
Pathways		ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	ISG15 antiviral mechanism RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Chronotype ( 30696823) Coffee consumption ( 31046077) General risk tolerance (MTAG) ( 30643258) Male-pattern baldness ( 28196072) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		29 interacting genes: ARIH1 BIRC2 BIRC5 CASP3 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 GABARAP HTRA2 MAP1LC3B MAP2K1 NEDD4 PLK1 RAB8A RACK1 RNF144A RNF4 RNF41 UBA6 UBC UBE2D1 UBE3C USP8 VAV2 VCL	20 interacting genes: BIRC6 CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PCBP1 PLD1 RBX1 SEC31A SLC25A21-AS1 UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		57448	25820
HPRD ID		05731	05730
Ensembl ID		ENSG00000115760	ENSG00000166233
Uniprot IDs		A0A8V8TQB4 A0A8V8TR92 Q9NR09	Q9Y4X5
PDB IDs		3CEG 8ATM 8ATO 8ATU 8ATX 8AUK 8AUW 8E2D 8E2E 8E2F 8E2G 8E2H 8E2I 8E2K	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH 7B5L 7B5M 7B5N 7B5S
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Ubiquitination Proteolysis Cytosol Protein Modification By Small Protein Conjugation Protein Modification Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Catabolic Process Programmed Cell Death Cell Death Midbody Mitotic Cytokinesis Response To Anesthetic Execution Phase Of Apoptosis Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Polyubiquitination Cytoskeleton-dependent Cytokinesis Response To Cobalt Ion CD40 Receptor Complex Regulation Of Macroautophagy Apoptotic Signaling Pathway Positive Regulation Of Protein Catabolic Process Signal Transduction Regulation Of Protein Localization Cytoplasm Transferase Activity Regulation Of Protein Catabolic Process Golgi Inheritance Positive Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Regulation Of Protein Metabolic Process Cysteine-type Endopeptidase Activity DNA Damage Response Cellular Response To Stress Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Localization To Site Of Double-strand Break Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Post-translational Protein Modification Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Protein Modification Process Protein Monoubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process ISG15 Transferase Activity Cytosol Protein K11-linked Ubiquitination Protein Metabolic Process ISG15-protein Conjugation Ubiquitin-dependent Protein Catabolic Process Cell Cycle Phase Transition Ubiquitin-protein Transferase Activator Activity TORC1 Signaling Negative Regulation Of TORC1 Signaling Cytoplasm Negative Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Cul4A-RING E3 Ubiquitin Ligase Complex Macromolecule Catabolic Process Cell Cycle G1/S Phase Transition TOR Signaling Negative Regulation Of TOR Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Response To Nutrient Levels Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination DNA Damage Response Ubiquitin Binding Ubiquitin-like Protein Transferase Activity Proteolysis Ubiquitin Ligase Complex Protein Neddylation Cullin Family Protein Binding
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